CAJ | 학술논문

目的：探讨西医常规治疗加用麝香保心丸对慢性充血性心力衰竭患者心功能及血管内皮功能的影响。方法将100例临床症状稳定的慢性充血性心力衰竭患者随机均分为治疗组和对照组，两组均予西医常规治疗，治疗组同时加用麝香保心丸，口服，每次2丸，每日3次。测定治疗前后左心室射血分数（LVEF）、左心室舒张末期容积（LVEDV）、6分钟步行距离试验（6MWT）、血浆内皮素1（ET －1）、血清一氧化氮（NO）。结果治疗24 d 后，治疗组总有效率为90.00%，明显高于对照组的84.00%( P ﹤0.05)。与治疗前比较，治疗组患者治疗后LVEF 及 LVEDV 和6MWT 均明显提高（ P ﹤0.05），对照组仅 LVEF 和6MWT 提高（ P ﹤0.05），且治疗组患者的 LVEDV 和6MWT 均优于对照组（ P ﹤0.05）。治疗组治疗后的 ET －1 及 NO 水平均显著提高( P ﹤0.05)，对照组仅 NO 水平提高( P ﹤0.05)，且治疗组患者的 ET －1及 NO 水平均显著高于对照组（ P ﹤0.05）。两组患者治疗前后血尿常规及肾功能均无明显变化，均未出现明显药品不良反应。结论西医治疗基础上加用麝香保心丸，能有效改善慢性充血性心力衰竭患者的心功能和血管内皮功能，安全性好，值得临床推广。
목적：탐토서의상규치료가용사향보심환대만성충혈성심력쇠갈환자심공능급혈관내피공능적영향。방법장100례림상증상은정적만성충혈성심력쇠갈환자수궤균분위치료조화대조조，량조균여서의상규치료，치료조동시가용사향보심환，구복，매차2환，매일3차。측정치료전후좌심실사혈분수（LVEF）、좌심실서장말기용적（LVEDV）、6분종보행거리시험（6MWT）、혈장내피소1（ET －1）、혈청일양화담（NO）。결과치료24 d 후，치료조총유효솔위90.00%，명현고우대조조적84.00%( P ﹤0.05)。여치료전비교，치료조환자치료후LVEF 급 LVEDV 화6MWT 균명현제고（ P ﹤0.05），대조조부 LVEF 화6MWT 제고（ P ﹤0.05），차치료조환자적 LVEDV 화6MWT 균우우대조조（ P ﹤0.05）。치료조치료후적 ET －1 급 NO 수평균현저제고( P ﹤0.05)，대조조부 NO 수평제고( P ﹤0.05)，차치료조환자적 ET －1급 NO 수평균현저고우대조조（ P ﹤0.05）。량조환자치료전후혈뇨상규급신공능균무명현변화，균미출현명현약품불량반응。결론서의치료기출상가용사향보심환，능유효개선만성충혈성심력쇠갈환자적심공능화혈관내피공능，안전성호，치득림상추엄。
Objective To investigate the effect of Shengxiangbaoxin Pills on the heart function and vascular endothelial function in the patients with chronic congestive heart failure. Methods 100 patients with the stable symptoms of chronic congestive heart failure were randomly divided to the treatment group and the control group. The two groups were treated by the routine Western medicine thera-py. The treatment group was simultaneously added with oral Shengxiangbaoxin Pill(2 pills each time, twice daily) . The change situation of left ventricular ejection fraction(LVEF), left ventricular end diastolic volume(LVEDV), 6 min walk distance test(6 MWT), plasma en-dothelin - 1(ET - 1) and nitric oxide(NO) before and after treatment was determined. Results The total effective rate after 24 d thera-py was 90. 00% , which was significantly higher than 84. 00% in the control group( P ﹤ 0. 05) . Compared with before treatment, LVEF, LVEDV and 6MWT after treatment were significantly increased ( P ﹤ 0. 05 ) , while only LVEF and 6MWT in the control group were increased( P ﹤ 0. 05); moreover the treatment group was significantly superior to the control group in LVEDV and 6MWT ET( P ﹤ 0. 05). The NO and ET - 1 levels after treatment in the treatment group were significantly higher than those in the control group( P ﹤ 0. 05), while only NO in the control group was increased( P ﹤ 0. 05) . The blood and urine routine and renal function in the two groups had no stat6istically significant difference between before and after treatment. No obvious adverse drug reactions occurred in the two groups. Conclusion Adding Shengxiangbaoxin on the basis of Western medicine therapy can effectively improve the heart function and vascular endothelial function in the patients with chronic congestive heart failure, has good safety and deserves to be clinically promoted.