CAJ | 학술논문

目的：比较喹硫平和利培酮治疗老年期痴呆精神行为症状的疗效和安全性。方法将55例老年期痴呆患者随机分为喹硫平组28例，利培酮组27例，共观察8周。治疗前及治疗后第2，4，8周分别采用阿尔茨海默病病理行为评定量表(BEHAVE － AD)评定疗效，采用不良反应量表（TESS）评定不良反应，采用简易智力状态检查(MMSE)评定认知功能。结果两组临床总有效率分别为82.14%和88.89%，无显著性差异( P ﹥0.05)；2组在治疗后2周末起 BEHAVE － AD 评分有显著下降( P ﹤0.01或 P ﹤0.05)，治疗结束后组间BEHAVE － AD 评分和 MMSE 评分均无显著性差异( P ﹥0.05)；两组锥体外系反应发生率比较有显著性差异，喹硫平组更低( P ﹤0.01)。结论喹硫平治疗老年期痴呆精神行为障碍疗效与利培酮相当，但锥体外系反应较利培酮少，更适用于老年患者。
목적：비교규류평화리배동치료노년기치태정신행위증상적료효화안전성。방법장55례노년기치태환자수궤분위규류평조28례，리배동조27례，공관찰8주。치료전급치료후제2，4，8주분별채용아이자해묵병병리행위평정량표(BEHAVE － AD)평정료효，채용불량반응량표（TESS）평정불량반응，채용간역지력상태검사(MMSE)평정인지공능。결과량조림상총유효솔분별위82.14%화88.89%，무현저성차이( P ﹥0.05)；2조재치료후2주말기 BEHAVE － AD 평분유현저하강( P ﹤0.01혹 P ﹤0.05)，치료결속후조간BEHAVE － AD 평분화 MMSE 평분균무현저성차이( P ﹥0.05)；량조추체외계반응발생솔비교유현저성차이，규류평조경저( P ﹤0.01)。결론규류평치료노년기치태정신행위장애료효여리배동상당，단추체외계반응교리배동소，경괄용우노년환자。
Objective To study the efficacy and safety of quetiapine and risperidone for treating mental and behavioral symptoms in el-derly patients with dementia. Methods 55 inpatients with senile dementia were randomly assigned into two groups and treated with quetiapine(28 cases) or risperidone(27 cases) for an 8 - week treatment. The AD pathological behavior rating scale (BEHAVE - AD) and the Treatment Emergent Symptoms Scale(TESS) were used to evaluate the curative efficacy and the adverse reactions before treat-ment and at the end of 2nd, 4th, 8th week after treatment. The mini - mental state examination(MMSE) was used to evaluate the cogni-tive function. Results The total effective rates after treatment in the quetiapine group and the risperidone group were 82. 14% and 88. 89% respectively, no statistically significant difference was found between the two groups( P ﹥ 0. 05); the BEHAVE - AD scores at the end of 2nd week in the two groups began to be significantly decreased( P ﹤ 0. 01 or P ﹤ 0. 05), with no statistically significant dif-ference between the two groups; the BEHAVE - AD scores and the MMSE scores at the end of treatment had no statistically significant differences between the two groups( P ﹥ 0. 05 ); the occurrence rate of extrapyramidal symptoms(EPS) had statistically significant differ-ence between the two groups( P ﹤ 0. 01). Conclusion Quetiapine is as effective as risperidone for treating senile dementia, but has few-er extrapyramidal reactions than risperidone and would be more suitable for elderly patients.