CAJ | 학술논문

1例25岁男性患者因慢性肾功不全导致低钙血症给予阿法骨化醇(0.5 μg,每晚1次)、复方α-酮酸(2.52 g,3次/d)、生血宁(0.5g,3次/d)口服,并皮下注射重组人促红素(2500 U,隔日1次).第15天实验室检查示丙氨酸转氨酶(ALT)411 U/L、天冬氨酸转氨酶(AST)341 U/L,给予还原型谷胱甘肽1.2g,1次/d静脉滴注.次日转氨酶水平继续增高,加用多烯磷脂酰胆碱465 mg,1次/d静脉滴注.第20天复查肝功能,ALT 1 768 U/L,AST 1 164 U/L,碱性磷酸酶338 U/L,γ-谷氨酰转移酶(γ-GT) 210 U/L.当日停用阿法骨化醇,其他药物继续使用.3d后,ALT 644 U/L,AST 206 U/L,γ-GT 254 U/L;14 d后,ALT 47 U/L,AST 58 U/L.
1례25세남성환자인만성신공불전도치저개혈증급여아법골화순(0.5 μg,매만1차)、복방α-동산(2.52 g,3차/d)、생혈저(0.5g,3차/d)구복,병피하주사중조인촉홍소(2500 U,격일1차).제15천실험실검사시병안산전안매(ALT)411 U/L、천동안산전안매(AST)341 U/L,급여환원형곡광감태1.2g,1차/d정맥적주.차일전안매수평계속증고,가용다희린지선담감465 mg,1차/d정맥적주.제20천복사간공능,ALT 1 768 U/L,AST 1 164 U/L,감성린산매338 U/L,γ-곡안선전이매(γ-GT) 210 U/L.당일정용아법골화순,기타약물계속사용.3d후,ALT 644 U/L,AST 206 U/L,γ-GT 254 U/L;14 d후,ALT 47 U/L,AST 58 U/L.
A 25-year-old man with chronic renal insufficiency received oral alfacalcidol 0.5 μg every night,compound α-Ketoacid 2.52 g thrice daily,Shengxuening (生血宁) 0.5 g thrice daily,and subcutaneous injection recombinant human erythropoietin 2500 U once every other day.On day 15,laboratory tests showed the following results:alanine aminotransferase (ALT) 411 U/L,aspartate aminotransferase (AST) 341 U/L.He was given an Ⅳ infusion of reduced glutathione 1.2 g once daily.The next day,aminotransferase levels continue to increase,combined with an Ⅳ infusion of polyene phosphatidylcholine 465 mg once daily.On day 20,his liver function reexamination showed the following levels:ALT 1 768 U/L,AST 1 164 U/L,alkaline phosphatase 338 U/L,gamma-glutamyl transferase (γ-GT) 210 U/L.The alfacalcidol was stopped at that day and other drugs were continued.Three days after withdrawal,the levels of ALT,AST,and γ-GT were 644 U/L,206 U/L,and 254 U/L,respectively.Fourteen days later,the level of ALT and AST decreased to 47 U/L and 58 U/L.