药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2015年
1期
61-62
,共2页
舍曲林%血清素摄取抑制药%血小板减少
捨麯林%血清素攝取抑製藥%血小闆減少
사곡림%혈청소섭취억제약%혈소판감소
Sertraline%Serotonin uptake inhibitors%Thrombocytopenia
1例75岁女性慢性阻塞性肺疾病患者因存在焦虑症和抑郁症给予舍曲林25 mg,1次/d口服.治疗前,患者血红蛋白140 g/L,血小板计数175×109/L.服药3d后,患者出现黑便,大便潜血阳性,血常规检查示血红蛋白60 g/L,血小板计数2×109/L.停用舍曲林,输注血小板2个治疗量,静脉注射地塞米松5 mg.次日血小板计数15×109/L,大便潜血试验转阴.停药第3、10天,血小板计数分别为25×109/L和85×109/L.停药第13天,血小板计数升至105×109/L.
1例75歲女性慢性阻塞性肺疾病患者因存在焦慮癥和抑鬱癥給予捨麯林25 mg,1次/d口服.治療前,患者血紅蛋白140 g/L,血小闆計數175×109/L.服藥3d後,患者齣現黑便,大便潛血暘性,血常規檢查示血紅蛋白60 g/L,血小闆計數2×109/L.停用捨麯林,輸註血小闆2箇治療量,靜脈註射地塞米鬆5 mg.次日血小闆計數15×109/L,大便潛血試驗轉陰.停藥第3、10天,血小闆計數分彆為25×109/L和85×109/L.停藥第13天,血小闆計數升至105×109/L.
1례75세녀성만성조새성폐질병환자인존재초필증화억욱증급여사곡림25 mg,1차/d구복.치료전,환자혈홍단백140 g/L,혈소판계수175×109/L.복약3d후,환자출현흑편,대편잠혈양성,혈상규검사시혈홍단백60 g/L,혈소판계수2×109/L.정용사곡림,수주혈소판2개치료량,정맥주사지새미송5 mg.차일혈소판계수15×109/L,대편잠혈시험전음.정약제3、10천,혈소판계수분별위25×109/L화85×109/L.정약제13천,혈소판계수승지105×109/L.
A 75-year-old woman with chronic obstructive pulmonary disease received sertraline 25 mg once daily for anxiety and depression.Her hemoglobin was 140 g/L and platelet count was 175 × 109/L before taking sertraline.Three days after drug administration,she presented with melena and was stool occult blood positive.Blood routine examination revealed that the hemoglobin was 60 g/L and platelet count was 2 × 109/L.Sertraline was stopped and two doses of platelet were transfused.Intravenous dexamethasone 5 mg was given.The next day,the platelet count was 15 × 109/L accompanied with the improvement in hematochezia.The platelet count reached 25 × 109/L and 85 × 109/L on the third day and tenth day after sertraline discontinuation respectively.On day 13,her platelet count returned to 105 × 109/L.
