药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2015年
1期
58-59
,共2页
药物过敏%心脏停搏%碘比醇
藥物過敏%心髒停搏%碘比醇
약물과민%심장정박%전비순
Drug hypersensitivity%Heart arrest%Iobitridol
1例74岁男性右股骨颈陈旧性骨折患者拟行CT血管造影检查以明确是否存在双下肢动脉硬化闭塞.造影前碘过敏试验阴性.开始静脉注射碘比醇后约1 min,患者突发意识丧失,脉搏消失,血压测不出.立即停止药物注射,迅速予氧气吸入、心肺复苏.5 min后,患者心率121次/min,血压86/47 mmHg(1 mmHg =0.133 kPa).予地塞米松10 mg、肾上腺素3 mg静脉注射.23 min后,患者心率119次/min,血压205/140 mmHg,出现躁动.29 min后,患者心率99次/min,心电图示窦性心律.继续予抗感染、改善心功能、减轻肺水肿等治疗.7d后,患者病情平稳.
1例74歲男性右股骨頸陳舊性骨摺患者擬行CT血管造影檢查以明確是否存在雙下肢動脈硬化閉塞.造影前碘過敏試驗陰性.開始靜脈註射碘比醇後約1 min,患者突髮意識喪失,脈搏消失,血壓測不齣.立即停止藥物註射,迅速予氧氣吸入、心肺複囌.5 min後,患者心率121次/min,血壓86/47 mmHg(1 mmHg =0.133 kPa).予地塞米鬆10 mg、腎上腺素3 mg靜脈註射.23 min後,患者心率119次/min,血壓205/140 mmHg,齣現躁動.29 min後,患者心率99次/min,心電圖示竇性心律.繼續予抗感染、改善心功能、減輕肺水腫等治療.7d後,患者病情平穩.
1례74세남성우고골경진구성골절환자의행CT혈관조영검사이명학시부존재쌍하지동맥경화폐새.조영전전과민시험음성.개시정맥주사전비순후약1 min,환자돌발의식상실,맥박소실,혈압측불출.립즉정지약물주사,신속여양기흡입、심폐복소.5 min후,환자심솔121차/min,혈압86/47 mmHg(1 mmHg =0.133 kPa).여지새미송10 mg、신상선소3 mg정맥주사.23 min후,환자심솔119차/min,혈압205/140 mmHg,출현조동.29 min후,환자심솔99차/min,심전도시두성심률.계속여항감염、개선심공능、감경폐수종등치료.7d후,환자병정평은.
A 74-year-old man with old fracture of right femoral neck was planned to undergo CT angiography to determine whether there were both lower extremities arteriosclerosis occlusion.The patient was negative for iodine anaphylactic test.About one minute after an Ⅳ injection of iobitridol start,the patient suddenly experienced loss of consciousness,asphygmia,and undetectable blood pressure.Iobitridol was stopped immediately and he was given oxygen inhalation and cardiopulmonary resuscitation immediately.Five minutes later,his heart rate was 121 beats per minute and blood pressure was 86/47 mmHg.An intravenous injection of dexamethasone 10 mg and epinephrine 3 mg were administered.Twenty-three minutes later,his heart rate was 119 beats per minute and blood pressure was 205/140 mmHg.Agitation appeared in the patient.Twenty-nine minutes later,his heart rate was 99 beats per minute and the electrocardiogram showed sinus rhythm.The patient was continuously treated with anti-infection,improvement of cardiac function,and alleviation of pulmonary edema.Seven days later,the patient's condition was stable.