中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
11期
32-34
,共3页
慢性特发性荨麻疹%免疫反应%B淋巴细胞刺激因子%抗IgE抗体%抗FcεRI抗体
慢性特髮性蕁痳疹%免疫反應%B淋巴細胞刺激因子%抗IgE抗體%抗FcεRI抗體
만성특발성담마진%면역반응%B림파세포자격인자%항IgE항체%항FcεRI항체
Chronic idiopathic urticaria%Immune response%B lymphocyte stimulating factor%Anti-IgE antibody%Anti-FcεRI antibody
目的：探讨慢性特发性荨麻疹患者血清B淋巴细胞刺激因子（BlyS）对抗IgE抗体和抗FcεRI抗体的影响。方法：选取慢性特发性荨麻疹患者100例作为疾病组，选取同期体检健康者100例作为健康组。检测两组受试者血清BlyS、抗IgE抗体及抗FcεRI抗体水平；分离培养疾病组患者外周血中的B淋巴细胞，分为两份保存，在其中一份培养液中加入有效水平的BlyS，检测抗IgE抗体及抗FcεRI抗体水平，作为试验组，将另一份作为空白对照组。分析血清BlyS与抗IgE抗体及抗FcεRI抗体之间的关系。结果：疾病组血清BlyS、抗IgE抗体及抗FcεRI抗体水平明显高于健康组，差异具有统计学意义（P<0.05）。试验组培养液中抗IgE抗体及抗FcεRI抗体水平明显高于对照组，差异具有统计学意义（P<0.05）；试验组中抗IgE抗体及抗FcεRI抗体水平与BlyS呈正相关（r=0.765、0.722，P<0.05）。结论：慢性特发性荨麻疹患者血清BlyS可刺激B淋巴细胞产生抗IgE抗体和抗FcεRI抗体，这可能与慢性特发性荨麻疹的发病机制有关。
目的：探討慢性特髮性蕁痳疹患者血清B淋巴細胞刺激因子（BlyS）對抗IgE抗體和抗FcεRI抗體的影響。方法：選取慢性特髮性蕁痳疹患者100例作為疾病組，選取同期體檢健康者100例作為健康組。檢測兩組受試者血清BlyS、抗IgE抗體及抗FcεRI抗體水平；分離培養疾病組患者外週血中的B淋巴細胞，分為兩份保存，在其中一份培養液中加入有效水平的BlyS，檢測抗IgE抗體及抗FcεRI抗體水平，作為試驗組，將另一份作為空白對照組。分析血清BlyS與抗IgE抗體及抗FcεRI抗體之間的關繫。結果：疾病組血清BlyS、抗IgE抗體及抗FcεRI抗體水平明顯高于健康組，差異具有統計學意義（P<0.05）。試驗組培養液中抗IgE抗體及抗FcεRI抗體水平明顯高于對照組，差異具有統計學意義（P<0.05）；試驗組中抗IgE抗體及抗FcεRI抗體水平與BlyS呈正相關（r=0.765、0.722，P<0.05）。結論：慢性特髮性蕁痳疹患者血清BlyS可刺激B淋巴細胞產生抗IgE抗體和抗FcεRI抗體，這可能與慢性特髮性蕁痳疹的髮病機製有關。
목적：탐토만성특발성담마진환자혈청B림파세포자격인자（BlyS）대항IgE항체화항FcεRI항체적영향。방법：선취만성특발성담마진환자100례작위질병조，선취동기체검건강자100례작위건강조。검측량조수시자혈청BlyS、항IgE항체급항FcεRI항체수평；분리배양질병조환자외주혈중적B림파세포，분위량빈보존，재기중일빈배양액중가입유효수평적BlyS，검측항IgE항체급항FcεRI항체수평，작위시험조，장령일빈작위공백대조조。분석혈청BlyS여항IgE항체급항FcεRI항체지간적관계。결과：질병조혈청BlyS、항IgE항체급항FcεRI항체수평명현고우건강조，차이구유통계학의의（P<0.05）。시험조배양액중항IgE항체급항FcεRI항체수평명현고우대조조，차이구유통계학의의（P<0.05）；시험조중항IgE항체급항FcεRI항체수평여BlyS정정상관（r=0.765、0.722，P<0.05）。결론：만성특발성담마진환자혈청BlyS가자격B림파세포산생항IgE항체화항FcεRI항체，저가능여만성특발성담마진적발병궤제유관。
Objective:To investigate the affect of the serum B lymphocytes stimulating factor(BlyS)on the anti-IgE antibody and anti-FcεRI antibody of the patients with chronic idiopathic urticaria. Method:100 cases of patients with chronic idiopathic urticaria were selected as disease group,100 cases of healthy people in the same period were selected as the healthy group. The serum level of the BlyS,anti-IgE antibody and anti-FcεRI antibodies were detected;the B lymphocytes from the peripheral blood of the disease group patients were isolated and cultured,and divided into two shares,add BlyS in one share as the experimental group,another share as blank control group,the level of the anti-IgE antibody and anti-FcεRI antibodies were detected. The relationship among the BlyS,anti-IgE antibody and anti-FcεRI antibodies were analyzed. Result:The serum levels of the BlyS,anti-IgE antibody and anti-FcεRI antibodies of the disease group were significantly higher than the healthy group,the differences had statistical significance(P<0.05). The levels of the BlyS,anti-IgE antibody and anti-FcεRI antibody of the experimental group were significantly higher than the control group,the differences had statistical significance(P<0.05). The levels of the anti-IgE antibody and anti-FcεRI antibodies of the experimental group were positively correlated with the BlyS(r=0.765,0.722,P<0.05). Conclusion:BlyS can stimulate B lymphocytes to produce the anti-IgE antibody and anti-FcεRI antibodies of patients with chronic idiopathic urticaria,this may be related to the pathogenesis of chronic idiopathic urticaria.
