CAJ | 학술논문

目的：探讨体外受精-胚胎移植（IVF-ET）周期中，卵泡期联合黄体期促排卵在卵巢低反应（P0R）患者中的应用及临床体会。方法：分析68例POR患者IVF周期中经卵泡期微刺激阶段和后续的黄体期促排卵阶段的平均获卵数、获卵比例、受精率、冷冻胚胎数、优质胚胎率及临产妊娠率指标。结果：两个阶段受精率、优质胚胎率比较差异均无统计学差异（P>O.05），但黄体期促排卵阶段的平均获卵数、获卵比例、冷冻胚胎数及临产妊娠率明显高于卵泡期阶段（P<O.05），而卵泡期联合黄体期取卵的平均获卵数、获卵比例、冰冻胚胎数明显多于单纯卵泡期取卵（P<0.05），最终临床妊娠人数达到14例。结论：在POR患者中，黄体期促排卵方案周期获卵数、冷冻胚胎数及临产妊娠率高，提示卵泡期联合黄体期促排卵方案能够有效改善POR患者的临床妊娠结局。
목적：탐토체외수정-배태이식（IVF-ET）주기중，란포기연합황체기촉배란재란소저반응（P0R）환자중적응용급림상체회。방법：분석68례POR환자IVF주기중경란포기미자격계단화후속적황체기촉배란계단적평균획란수、획란비례、수정솔、냉동배태수、우질배태솔급임산임신솔지표。결과：량개계단수정솔、우질배태솔비교차이균무통계학차이（P>O.05），단황체기촉배란계단적평균획란수、획란비례、냉동배태수급임산임신솔명현고우란포기계단（P<O.05），이란포기연합황체기취란적평균획란수、획란비례、빙동배태수명현다우단순란포기취란（P<0.05），최종림상임신인수체도14례。결론：재POR환자중，황체기촉배란방안주기획란수、냉동배태수급임산임신솔고，제시란포기연합황체기촉배란방안능구유효개선POR환자적림상임신결국。
Objective:To investigate the application and clinical experience with follicular phase mild ovarian stimulation joint luteal phase ovarian stimulation applied for in patients with poor ovarian response(P0R)in the cycle of in vitro fertilization and embryo transfer(IVF-ET).Method:Totally 68 patients with POR were applied IVF cycles,They all accepted follicular phase mild ovarian stimulation and the subsequent luteal phase ovarian stimulation,The clinical data including average number of retrieved oocytes and proportion of retrieved oocytes,fertilization rate and number of frozen embryos,rate of embryo high quality and pregnancy rate in labor were analyzed.Result:The fertilization rate and rate of embryo high quality of two phases not statistical difference(P>0.05),but the average number of retrieved oocytes, proportion of retrieved oocytes,number of frozen embryos and pregnancy rate of luteal phase ovarian stimulation were significantly higher than follicular phase(P<0.05),and the average number of retrieved oocytes,proportion of retrieved oocytes,number of frozen embryos of follicular phase mild ovarian stimulation joint luteal phase ovarian stimulation significantly more than simply follicular phase(P<0.05),and 14 patients were pregnancied ultimately.Conclusion:In patients with POR receive luteal phase ovarian stimulation made the average number of retrieved oocytes,number of frozen embryos and pregnancy rate higher,and follicular phase mild ovarian stimulation joint luteal phase ovarian stimulation applied for in patients with(P0R)can effectively improve the clinical pregnancy outcome.