CAJ | 학술논문

目的：探讨针刺治疗对痤疮患者疗效及免疫功能的影响。方法选取2013年1月至2013年6月济宁市第一人民医院皮肤科及针灸科门诊就诊的痤疮患者118例。按照随机数字表法将患者随机分为两组，治疗组50例采用针刺取穴治疗，对照组50例给予异维 A 酸口服治疗。治疗8周后进行两组患者疗效评价，并测定两组患者治疗前后血清白细胞介素2（IL-2）、IL-4、IL-10和γ型干扰素（INF-γ）的含量，并观察结果。采用 SPSS17.0统计学软件进行数据分析。两组间有效率比较采用χ2检验,计量资料比较采用两独立样本 t 检验。以 P<0.05为差异有统计学意义。结果治疗8周后，治疗组痊愈24例，显效21例，有效3例，总有效率96%（48/50）；对照组痊愈15例，显效12例，有效14例，总有效率82%（41/50）。两组疗效比较，差异有统计学意义（χ2=5.00, P<0.05）。治疗后，两组患者 IL-2、IL-4、IL-10和 INF-γ含量比较，差异均有统计学意义（t=17.84、13.48、25.12、14.31，P<0.05）。结论针刺治疗对痤疮患者临床疗效和免疫功能具有明显调节作用。
목적：탐토침자치료대좌창환자료효급면역공능적영향。방법선취2013년1월지2013년6월제저시제일인민의원피부과급침구과문진취진적좌창환자118례。안조수궤수자표법장환자수궤분위량조，치료조50례채용침자취혈치료，대조조50례급여이유 A 산구복치료。치료8주후진행량조환자료효평개，병측정량조환자치료전후혈청백세포개소2（IL-2）、IL-4、IL-10화γ형간우소（INF-γ）적함량，병관찰결과。채용 SPSS17.0통계학연건진행수거분석。량조간유효솔비교채용χ2검험,계량자료비교채용량독립양본 t 검험。이 P<0.05위차이유통계학의의。결과치료8주후，치료조전유24례，현효21례，유효3례，총유효솔96%（48/50）；대조조전유15례，현효12례，유효14례，총유효솔82%（41/50）。량조료효비교，차이유통계학의의（χ2=5.00, P<0.05）。치료후，량조환자 IL-2、IL-4、IL-10화 INF-γ함량비교，차이균유통계학의의（t=17.84、13.48、25.12、14.31，P<0.05）。결론침자치료대좌창환자림상료효화면역공능구유명현조절작용。
Objective To explore the effect of acupuncture therapy on immune function in patients with acne. Methods A total of 118 cases with acne from the acupuncture department and dermatology department of Jining City First People’s Hospital were included in this study during the period from January to June of 2013. Patients were randomly assigned to the treatment group with acupuncture treatment (n=50) and control group with oral isotretinoin treatment (n=50). The efficacy was evaluated after eight-week therapy in two groups. The serum levels of interleukin-2 (IL-2), IL-4, IL-10 and interferon interferon-γ (INF-γ) were detected before and after treatment. Data were analyzed by SPSS17.0 statistical software. The curative effect of the two groups was compared by the χ 2 test .Measurement data by using two independent sample t-test. P<0.05 was considered significant. Results After eight-week therapy, there were 24 cured, 21 markedly improved and 3 improved, with the total effective rate 96% (48/50), in treatment group. There were 15 cured, 12 markedly improved and 14 improved, with the total effective rate 82%(41/50), in control group. There was significant difference between two groups ( χ 2= 5.00 , P<0.05). There were significant differences in serum levels of IL-2, IL-4, IL-10 and INF-γ after acupuncture treatment between two groups (t=17.84, 13.48, 25.12 and 14.31, P<0.05). Conclusion Acupuncture has significant regulatory effect on immune function in patients with acne.