中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
8期
27-28,29
,共3页
乌司他丁%重症急性胰腺炎%腹内高压%老年
烏司他丁%重癥急性胰腺炎%腹內高壓%老年
오사타정%중증급성이선염%복내고압%노년
ulinastatin%severe acute pancreatitis%intra-abdominal hypertension%elderly
目的：探讨乌司他丁治疗老年重症急性胰腺炎（SAP）伴发腹内高压（IAH）患者的临床疗效。方法选取60岁以上SAP合并IAH患者62例，随机分为两组，各31例。两组患者均给予常规治疗，治疗组患者加用10万U乌司他丁，均治疗1周。于治疗前后测定患者腹内压（IAP）、肿瘤坏死因子－α（TNF－α）、白细胞介素（IL )－6）、血浆二胺氧化酶（DAO）、免疫球蛋白A（IgA）的水平，并评价其临床疗效。结果治疗组总有效率为93.55%，明显高于对照组的70.97%（ P ＜0.05）；治疗7 d后，两组患者的IAP，TNF－α，IL－6，DAO， IgA均较其治疗前有显著改善（ P＜0.05），治疗组改善幅度均显著大于对照组（ P＜0.05）。结论在常规治疗基础上加用乌司他丁治疗可提高老年SAP合并IAH患者的临床疗效，并可改善患者腹内压和肠黏膜的屏障功能。
目的：探討烏司他丁治療老年重癥急性胰腺炎（SAP）伴髮腹內高壓（IAH）患者的臨床療效。方法選取60歲以上SAP閤併IAH患者62例，隨機分為兩組，各31例。兩組患者均給予常規治療，治療組患者加用10萬U烏司他丁，均治療1週。于治療前後測定患者腹內壓（IAP）、腫瘤壞死因子－α（TNF－α）、白細胞介素（IL )－6）、血漿二胺氧化酶（DAO）、免疫毬蛋白A（IgA）的水平，併評價其臨床療效。結果治療組總有效率為93.55%，明顯高于對照組的70.97%（ P ＜0.05）；治療7 d後，兩組患者的IAP，TNF－α，IL－6，DAO， IgA均較其治療前有顯著改善（ P＜0.05），治療組改善幅度均顯著大于對照組（ P＜0.05）。結論在常規治療基礎上加用烏司他丁治療可提高老年SAP閤併IAH患者的臨床療效，併可改善患者腹內壓和腸黏膜的屏障功能。
목적：탐토오사타정치료노년중증급성이선염（SAP）반발복내고압（IAH）환자적림상료효。방법선취60세이상SAP합병IAH환자62례，수궤분위량조，각31례。량조환자균급여상규치료，치료조환자가용10만U오사타정，균치료1주。우치료전후측정환자복내압（IAP）、종류배사인자－α（TNF－α）、백세포개소（IL )－6）、혈장이알양화매（DAO）、면역구단백A（IgA）적수평，병평개기림상료효。결과치료조총유효솔위93.55%，명현고우대조조적70.97%（ P ＜0.05）；치료7 d후，량조환자적IAP，TNF－α，IL－6，DAO， IgA균교기치료전유현저개선（ P＜0.05），치료조개선폭도균현저대우대조조（ P＜0.05）。결론재상규치료기출상가용오사타정치료가제고노년SAP합병IAH환자적림상료효，병가개선환자복내압화장점막적병장공능。
Objective To investigate the efficacy of ulinastatin for treating elderly severe acute pancreatitis(SAP)complicating intra-ab-dominal hypertension(IAH). Methods 62 elderly patients (> 60 years old ) with SAP complicating IAH were randomly divided into two groups,31 cases in each group. The control group was given the conventional treatment and the treatment group was additionally treated with 100 000 unit of ulinastatin per day. All patients were treated for 1 week. The clinical data were collected before and after treat-ment,including intra-abdominal pressure(IAP),tumor necrosis factor-α(TNF-α),interleukin(IL ) -6,plasma diamine oxidase(DAO), immunoglobulin A(IgA). The clinical effects of two groups were evaluated. Results The total effective rate of the treatment group was 93. 55%,which was significantly higher than 70. 97% in the control group( P < 0. 05). IAP,TNF-α,IL-6,DAO and IgA after 7 d treatment in the two groups were significantly improved compared with those before treatment( P < 0. 05). The ameliorative amplitude of those indexes in the treatment group was significantly higher than that in the control group( P < 0. 05). Conclusion Adding ulinastatin on the basis of conventional treatment can greatly improve the clinical effect of elderly SAP complicating IAH,and also improve the IAP and intestinal barrier function.
