CAJ | 학술논문

目的：研究中药合剂治疗慢性肾衰竭（CRF）对血钾浓度的影响。方法将200例慢性肾衰竭患者随机分为治疗组和对照组，各100例，两组患者给予常规西医对症支持治疗，治疗组加用中药合剂。治疗2个月，观察血钾（K+）及内生肌酐清除率（Ccr）、血肌酐（SCr）、尿素氮（BUN）、尿酸（UA）、电解质、血红蛋白（Hb）、胱抑素C（Cys－C）、β2微球蛋白（β2－MG）、视黄醇结合蛋白（RBP）等实验室指标变化。结果治疗期间治疗组血 K+水平持续降低，与对照组同期K+水平比较，差异有统计学意义（ P＜0.05）；治疗2个月后，治疗组Scr， BUN，UA，Hb，Cys－C，β2－MG，RBP与对照组比较，差异均有统计学意义（ P＜0.05）。结论中药合剂可以降低慢性肾衰竭患者血钾浓度，这种作用与中药合剂保护肾脏残存功能、对抗代谢紊乱关系密切。
목적：연구중약합제치료만성신쇠갈（CRF）대혈갑농도적영향。방법장200례만성신쇠갈환자수궤분위치료조화대조조，각100례，량조환자급여상규서의대증지지치료，치료조가용중약합제。치료2개월，관찰혈갑（K+）급내생기항청제솔（Ccr）、혈기항（SCr）、뇨소담（BUN）、뇨산（UA）、전해질、혈홍단백（Hb）、광억소C（Cys－C）、β2미구단백（β2－MG）、시황순결합단백（RBP）등실험실지표변화。결과치료기간치료조혈 K+수평지속강저，여대조조동기K+수평비교，차이유통계학의의（ P＜0.05）；치료2개월후，치료조Scr， BUN，UA，Hb，Cys－C，β2－MG，RBP여대조조비교，차이균유통계학의의（ P＜0.05）。결론중약합제가이강저만성신쇠갈환자혈갑농도，저충작용여중약합제보호신장잔존공능、대항대사문란관계밀절。
Objective To research the influence of traditional Chinese medicine mixture on blood potassium concentration in the treatment of chronic renal failure(CRF). Methods Totally 200 patients with CRF were randomly divided into the treatment group and the control group with 100 cases in each group. The two groups were given the conventional Western medicine symptomatic treatment,while the treat-ment group was added with Chinese medicine mixture. The changes of blood potassium(K+),endogenous creatinine clearance rate(Ccr), serum creatinine(SCr),blood urea nitrogen(BUN),uric acid(UA),electrolytes,hemoglobin(Hb),cystatin C(Cys-C),β2 microglobulin(β2-MG)and retinol binding protein(RBP)were observed after the 2-month therapy. Results The blood K+ level during treatment in the treatment group was continuously decreasing,showing statistically significant difference compared with the control group( P < 0. 05);SCr, BUN,UA,Hb,Cys-C,β2-MG and RBP after the 2-month treatment had statistical differences between the two groups( P < 0. 05). Conclusion The traditional Chinese medicine mixture can reduce the blood potassium concentration in CRF patients,and this effect is closely related with the traditional Chinese mixture protecting the residual renal function and antagonizing the metabolic disorders.