CAJ | 학술논문

目的：评价他汀类药物治疗对心脏舒张功能及运动后血浆脑利钠肽（ BNP）水平的影响。方法随机将60例心脏舒张功能不全合并运动高血压患者分成阿托伐他汀治疗组和对照组各30例。在原有治疗基础上，治疗组加用阿托伐他汀20 mg，每晚1次，对照组则加用安慰剂，疗程1年。测定治疗前后患者的心功能、运动心肺功能和运动后血浆BNP浓度。结果治疗后，治疗组的二尖瓣血流频谱E峰与A峰比值（ E／A）有明显改善，运动时间延长，运动当量、运动最大摄氧量、无氧阈值均明显增大，运动 BNP明显下降，与治疗前相比差异均有统计学意义（ P＜0.05）；治疗后与对照组相比，E／A、运动时间、运动BNP浓度差异有统计学意义（ P＜0.05）。结论阿托伐他汀治疗能改善心脏舒张功能，降低运动BNP水平，提高运动耐量。
목적：평개타정류약물치료대심장서장공능급운동후혈장뇌리납태（ BNP）수평적영향。방법수궤장60례심장서장공능불전합병운동고혈압환자분성아탁벌타정치료조화대조조각30례。재원유치료기출상，치료조가용아탁벌타정20 mg，매만1차，대조조칙가용안위제，료정1년。측정치료전후환자적심공능、운동심폐공능화운동후혈장BNP농도。결과치료후，치료조적이첨판혈류빈보E봉여A봉비치（ E／A）유명현개선，운동시간연장，운동당량、운동최대섭양량、무양역치균명현증대，운동 BNP명현하강，여치료전상비차이균유통계학의의（ P＜0.05）；치료후여대조조상비，E／A、운동시간、운동BNP농도차이유통계학의의（ P＜0.05）。결론아탁벌타정치료능개선심장서장공능，강저운동BNP수평，제고운동내량。
Objective To evaluate the effects of statin on cardiac dias-tolic function and the level of B -type natriuretic peptide ( BNP) to exer-cise.Methods A total of 60 patients with diastolic dysfunction and a hypertensive response to exercise were divided into atorvastatin treatment group( n =30, atorvastatin 20 mg, once every night ) and the placebo group(n=30).The course of treatment was one year , all patients con-tinued their original therapy.Echocardiography , cardiopulmonary exer-cise testing , and the plasma BNP concentration determination at peak exercise were performed before and after treatment.Results After ator-vastatin treatment , the mitral flow velocity E wave to A wave peak veloci-ties( E/A ratio) were improved.The exercise time extended , metabolic equivalents , maximal oxygen uptake and anaerobic threshold were increased , and the exercise BNP values reduced.All of parameters had significant difference from baseline (P<0.05), only the E/A ratio,the exercise time and the exercise BNP values had significant difference com-pared with placebo ( P<0.05 ).Conclusion Atorvastatin improves car-diac diastolic function , decreases exercise BNP level , increases exercise tolerance.