中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
7期
495-497
,共3页
郑学宝%王洪飞%吴新君%郑维芳
鄭學寶%王洪飛%吳新君%鄭維芳
정학보%왕홍비%오신군%정유방
奥氮平%草酸艾司西酞普兰%老年%抑郁症%临床疗效
奧氮平%草痠艾司西酞普蘭%老年%抑鬱癥%臨床療效
오담평%초산애사서태보란%노년%억욱증%림상료효
olanzapine%escitalopram oxalate%elderly%depressive disorder%clinical efficacy
目的:评价草酸艾司西酞普兰联合奥氮平治疗老年抑郁症的临床疗效及安全性。方法入选2012年2月至2014年4月我科收治的老年抑郁症患者62例为研究对象,随机分为奥氮平联合草酸艾司西酞普兰治疗组(试验组,n=29)和草酸艾司西酞普兰组(对照组, n=33)。对照组给予草酸艾司西酞普兰10 mg· d-1口服,疗程8周;试验组在对照组的基础上,加用奥氮平起始剂量2.5 mg· d-1,1周内可加至5~10 mg· d-1,疗程8周。2组患者分别在治疗前及治疗后1,2,4,6,8周末时,用汉密尔顿抑郁量表( HAMD)及相关不良反应量表( TESS)评估2组患者临床疗效及不良反应。结果治疗2周末至8周末,2组患者HAMD评分较治疗前均显著降低(均P<0.05);治疗4周末至8周,试验组HAMD评分较对照组显著降低(均P<0.05)。8周末时,试验组10%以上患者体重增加显著高于对照组( P<0.05);而其他不良反应(如头晕、口干、便秘、恶心等)的发生率比较,差异无统计学意义(均P>0.05)。结论奥氮平联合草酸艾司西酞普兰治疗老年抑郁症起效快,临床疗效较单用草酸艾司西酞普兰好,但可显著增加患者体重。
目的:評價草痠艾司西酞普蘭聯閤奧氮平治療老年抑鬱癥的臨床療效及安全性。方法入選2012年2月至2014年4月我科收治的老年抑鬱癥患者62例為研究對象,隨機分為奧氮平聯閤草痠艾司西酞普蘭治療組(試驗組,n=29)和草痠艾司西酞普蘭組(對照組, n=33)。對照組給予草痠艾司西酞普蘭10 mg· d-1口服,療程8週;試驗組在對照組的基礎上,加用奧氮平起始劑量2.5 mg· d-1,1週內可加至5~10 mg· d-1,療程8週。2組患者分彆在治療前及治療後1,2,4,6,8週末時,用漢密爾頓抑鬱量錶( HAMD)及相關不良反應量錶( TESS)評估2組患者臨床療效及不良反應。結果治療2週末至8週末,2組患者HAMD評分較治療前均顯著降低(均P<0.05);治療4週末至8週,試驗組HAMD評分較對照組顯著降低(均P<0.05)。8週末時,試驗組10%以上患者體重增加顯著高于對照組( P<0.05);而其他不良反應(如頭暈、口榦、便祕、噁心等)的髮生率比較,差異無統計學意義(均P>0.05)。結論奧氮平聯閤草痠艾司西酞普蘭治療老年抑鬱癥起效快,臨床療效較單用草痠艾司西酞普蘭好,但可顯著增加患者體重。
목적:평개초산애사서태보란연합오담평치료노년억욱증적림상료효급안전성。방법입선2012년2월지2014년4월아과수치적노년억욱증환자62례위연구대상,수궤분위오담평연합초산애사서태보란치료조(시험조,n=29)화초산애사서태보란조(대조조, n=33)。대조조급여초산애사서태보란10 mg· d-1구복,료정8주;시험조재대조조적기출상,가용오담평기시제량2.5 mg· d-1,1주내가가지5~10 mg· d-1,료정8주。2조환자분별재치료전급치료후1,2,4,6,8주말시,용한밀이돈억욱량표( HAMD)급상관불량반응량표( TESS)평고2조환자림상료효급불량반응。결과치료2주말지8주말,2조환자HAMD평분교치료전균현저강저(균P<0.05);치료4주말지8주,시험조HAMD평분교대조조현저강저(균P<0.05)。8주말시,시험조10%이상환자체중증가현저고우대조조( P<0.05);이기타불량반응(여두훈、구간、편비、악심등)적발생솔비교,차이무통계학의의(균P>0.05)。결론오담평연합초산애사서태보란치료노년억욱증기효쾌,림상료효교단용초산애사서태보란호,단가현저증가환자체중。
Objective To assess the clinical efficacy and adverse reac-tions of olanzapine combined with escitalopram oxalate on depressive disorder in elderly patients.Methods Sixty two elderly patients with depressive disorder were recruited from February 2012 to April 2014 in our hospital and were randomized divided into the control group ( n=33 ) and experiment group ( n=29 ).Patients in the control group were given escitalopram oxalate 10 mg · d-1 orally for 8 weeks and patients in the experiment group were given escitalopram oxalate 10 mg · d-1 combined olanzapine 2.5 mg· d-1 ( initially) ,ranging from 5 to 10 mg· d-1 within the first week.The data of hamilton depression scale ( HAMD) and treat-ment emergent symptom scale ( TESS ) score were recorded between the two groups to evaluate the clinical efficacy and adverse reactions before treatment and 1, 2, 4, 6 and 8 weeks after treatment.Results From the end of the second week to the eighth week , the HAMD scale were significantly decreased in both groups ( P <0.05 ).At the end of the fourth week to the eighth week , the HAMD score in the experiment group were significantly lower than those in control group ( P <0.05 ).After 8 weeks, more than 10%patients in the experiment group showed weight gain , higher than those in the control group (P<0.05).The other adverse reactions such as dizziness , dry mouth, constipation and nausea showed no statistical differences( P>0.05 ).Conclusion Olanzapine combined with escitalopram oxalate in the treatment of depressive disorder in elderly patients can rapidly improve the symptom and have better clinical efficacy , but the weight gain was a common adverse reaction.