中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
10期
9-12
,共4页
降钙素原%C反应蛋白%系统性%红斑狼疮%发热
降鈣素原%C反應蛋白%繫統性%紅斑狼瘡%髮熱
강개소원%C반응단백%계통성%홍반랑창%발열
Procalcitonin%C-reactive protein%Systemic%Lupus erythematosus%Fever
目的：探讨降钙素原（PCT）及C反应蛋白（CRP）检测在系统性红斑狼疮（SLE）合并发热患者中的价值。方法回顾性分析52例SLE伴发热的患者，并与15例单纯感染患者对照，将其分为SLE合并感染组（22例）、单纯SLE组（30例）及单纯感染组（15例），比较三组PCT、CRP水平以及比较SLE合并感染组治疗前后PCT、CRP水平，并分析SLE患者中PCT、CRP与狼疮活动指标的关系，比较PCT、CRP单独及联合检测在诊断SLE合并感染的特异性及敏感性。结果 SLE合并感染组PCT、CRP水平显著高于单纯SLE组；单纯感染组PCT及CRP与SLE合并感染组比较无显著性差异，但与单纯SLE组之间比较差异有统计学意义；两SLE组不同活动度间PCT及CRP水平比较无显著性差异；PCT的特异性及敏感性均较CRP高，但差异均无统计学意义；PCT与CRP联合检测的特异性及敏感性明显高于单独检测CRP，和单独检测PCT比较，特异性明显提高，但敏感性无明显差异。结论PCT、CRP浓度在多数SLE合并感染患者中升高，对于鉴别狼疮感染与活动有一定临床价值，两者联合检测更可提高临床诊断价值。
目的：探討降鈣素原（PCT）及C反應蛋白（CRP）檢測在繫統性紅斑狼瘡（SLE）閤併髮熱患者中的價值。方法迴顧性分析52例SLE伴髮熱的患者，併與15例單純感染患者對照，將其分為SLE閤併感染組（22例）、單純SLE組（30例）及單純感染組（15例），比較三組PCT、CRP水平以及比較SLE閤併感染組治療前後PCT、CRP水平，併分析SLE患者中PCT、CRP與狼瘡活動指標的關繫，比較PCT、CRP單獨及聯閤檢測在診斷SLE閤併感染的特異性及敏感性。結果 SLE閤併感染組PCT、CRP水平顯著高于單純SLE組；單純感染組PCT及CRP與SLE閤併感染組比較無顯著性差異，但與單純SLE組之間比較差異有統計學意義；兩SLE組不同活動度間PCT及CRP水平比較無顯著性差異；PCT的特異性及敏感性均較CRP高，但差異均無統計學意義；PCT與CRP聯閤檢測的特異性及敏感性明顯高于單獨檢測CRP，和單獨檢測PCT比較，特異性明顯提高，但敏感性無明顯差異。結論PCT、CRP濃度在多數SLE閤併感染患者中升高，對于鑒彆狼瘡感染與活動有一定臨床價值，兩者聯閤檢測更可提高臨床診斷價值。
목적：탐토강개소원（PCT）급C반응단백（CRP）검측재계통성홍반랑창（SLE）합병발열환자중적개치。방법회고성분석52례SLE반발열적환자，병여15례단순감염환자대조，장기분위SLE합병감염조（22례）、단순SLE조（30례）급단순감염조（15례），비교삼조PCT、CRP수평이급비교SLE합병감염조치료전후PCT、CRP수평，병분석SLE환자중PCT、CRP여랑창활동지표적관계，비교PCT、CRP단독급연합검측재진단SLE합병감염적특이성급민감성。결과 SLE합병감염조PCT、CRP수평현저고우단순SLE조；단순감염조PCT급CRP여SLE합병감염조비교무현저성차이，단여단순SLE조지간비교차이유통계학의의；량SLE조불동활동도간PCT급CRP수평비교무현저성차이；PCT적특이성급민감성균교CRP고，단차이균무통계학의의；PCT여CRP연합검측적특이성급민감성명현고우단독검측CRP，화단독검측PCT비교，특이성명현제고，단민감성무명현차이。결론PCT、CRP농도재다수SLE합병감염환자중승고，대우감별랑창감염여활동유일정림상개치，량자연합검측경가제고림상진단개치。
Objective To evaluate the clinical diagnosis value of procalcitonin(PCT)and C-reactive protein(CRP)in patients of systemic lupus erythematosus (SLE) with fever. Methods Prospectively selected 52 cases of SLE patients with fever,and contrast to 15 patients of simple infection group,enrolled SLE with infection group(22 cases),simple SLE group (30 cases) and simple infection group(15 cases). Three groups of PCT and CRP levels, compared PCT and CRP levels of SLE with infection before and after treatment, and the relationship between PCT and CRP and lu-pus activity indicators in SLE patients were analyzed. The sensitivity and specificity with the separate and combined detection PCT and CRP levels for the diagnosis of SLE with infection were compared. Results The PCT and CRP levels of SLE with infection were significantly higher than the levels of simple SLE group.The PCT and CRP levels of simple infection group had no statistical difference between SLE with infection group,but the difference between simple SLE group was statistically significant. In two SLE group with different activity PCT and CRP levels had no significant dif-ference. The sensitivity and specificity of PCT compared with CRP was higher,but the difference had no statistically significant. The sensitivity and specificity in PCT and CRP combined detection were higher than separate detection CRP. Compared with separate detection PCT,the sensitivity was not significant difference,but specificity significantly increased. Conclusion The levels of PCT and CRP increase in most SLE patients with infectiont, detecting PCT and CRP is useful to distinguish infection and lupus activity,the combined detection can improve the diagnostic value.
