中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
7期
523-525
,共3页
痰热清注射液%盐酸左氧氟沙星胶囊%细胞因子%甲状腺素%全身炎症反应综合征
痰熱清註射液%鹽痠左氧氟沙星膠囊%細胞因子%甲狀腺素%全身炎癥反應綜閤徵
담열청주사액%염산좌양불사성효낭%세포인자%갑상선소%전신염증반응종합정
Tanreqing Injection%ofloxacin hydrochloride%cytokines%thyroxine%systemic inflammatory response syndrome
目的：探讨中西医联合干预、预防或减轻经皮肾镜取石围手术期全身炎症反应综合征的效果。方法模拟人体进行微通道经皮肾镜取石术围手术期处理和手术过程，选择雄性新西兰大白兔制作动物模型，实验组20只，对照组5只；2组均灌服盐酸左氧氟沙星胶囊25 mg，1日1次；于术后0.5 h开始，实验组静脉注射痰热清注射液0.3～0.5 mL·（ kg· d）－1，1日1次，均连用7 d，对照组注射等量0.9％氯化钠。选不同时间段抽取外周静脉血，监测白细胞介素－2（ IL－2）、白细胞介素－6（ IL －6）、肿瘤坏死因子（ TNF）及甲状腺激素（ TT4、TT3）的变化。结果 IL－2、TT4、TT3的变化是先降后升，而IL－6、TNF是先升高后回落；实验组恢复程度明显好于对照组。结论中西医联合干预经皮肾镜取石围手术期对预防或减轻全身炎症反应综合征起积极的作用。
目的：探討中西醫聯閤榦預、預防或減輕經皮腎鏡取石圍手術期全身炎癥反應綜閤徵的效果。方法模擬人體進行微通道經皮腎鏡取石術圍手術期處理和手術過程，選擇雄性新西蘭大白兔製作動物模型，實驗組20隻，對照組5隻；2組均灌服鹽痠左氧氟沙星膠囊25 mg，1日1次；于術後0.5 h開始，實驗組靜脈註射痰熱清註射液0.3～0.5 mL·（ kg· d）－1，1日1次，均連用7 d，對照組註射等量0.9％氯化鈉。選不同時間段抽取外週靜脈血，鑑測白細胞介素－2（ IL－2）、白細胞介素－6（ IL －6）、腫瘤壞死因子（ TNF）及甲狀腺激素（ TT4、TT3）的變化。結果 IL－2、TT4、TT3的變化是先降後升，而IL－6、TNF是先升高後迴落；實驗組恢複程度明顯好于對照組。結論中西醫聯閤榦預經皮腎鏡取石圍手術期對預防或減輕全身炎癥反應綜閤徵起積極的作用。
목적：탐토중서의연합간예、예방혹감경경피신경취석위수술기전신염증반응종합정적효과。방법모의인체진행미통도경피신경취석술위수술기처리화수술과정，선택웅성신서란대백토제작동물모형，실험조20지，대조조5지；2조균관복염산좌양불사성효낭25 mg，1일1차；우술후0.5 h개시，실험조정맥주사담열청주사액0.3～0.5 mL·（ kg· d）－1，1일1차，균련용7 d，대조조주사등량0.9％록화납。선불동시간단추취외주정맥혈，감측백세포개소－2（ IL－2）、백세포개소－6（ IL －6）、종류배사인자（ TNF）급갑상선격소（ TT4、TT3）적변화。결과 IL－2、TT4、TT3적변화시선강후승，이IL－6、TNF시선승고후회락；실험조회복정도명현호우대조조。결론중서의연합간예경피신경취석위수술기대예방혹감경전신염증반응종합정기적겁적작용。
Objective To explore effects of traditional Chinese medicine and western medicine combined for prevent or reduce the systemic infla-mmatory response syndrome ( SIRS) in peri-operation period of percuta-neous nephroscope.Methods The microchannel percutaneous nephro-lithotomy perioperative management and operation process in peri -operation period of human were simulated.The male white rabbits of New Zealand were selected to produce animal model , which were divided into test group ( n=20 ) , control group ( n=5 ).The rabbits were given oflo-xacin hydrochloride 25 mg every time, once a day for 7days in two groups.And then the rabbits in test goup were intravenously the Tan-reqing Injection 0.3~0.5 mL · ( kg · d ) -1 every time , once a day for 7days.The level of interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor ( TNF) , thyroid hormone ( TT4 , TT3 ) were detected from peripheral venous blood of the rabbits on multiple time periods ( preoper-ative, postoperative 1 day, 3 days and 7 days).Results The level of IL -2, TT4 and TT3 were found to drop significantly at first and to re-bound afterwards , while the concentration of IL -6 and TNF were de-tected to rise at first and fall back afterwards.The effect of the drugs in test group was found to be better than the control group significantly.Conclusion Traditional Chinese and western medicine combined intervention take a positive role in preventing or reducing the SIRS.
