中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
10期
16-18
,共3页
妊娠晚期%25-羟维生素D3%胰岛素抵抗%骨代谢
妊娠晚期%25-羥維生素D3%胰島素牴抗%骨代謝
임신만기%25-간유생소D3%이도소저항%골대사
Late pregnancy%25-hydroxyl vitamin D3%Insulin resistance%Bone metabolism
目的：探讨妊娠晚期血清25-羟维生素D3对胰岛素抵抗、骨代谢的影响。方法以2012年2月~2013年1月到我院接受产前检查的84例妊娠晚期孕妇为研究对象，根据糖尿病患病情况分为妊娠晚期糖尿病组和妊娠晚期健康组，使用全自动生化分析仪检测两组患者的甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）、空腹血糖（FBG）水平。使用自动发光免疫分析测定空腹胰岛素（FINS）、血清25-羟维生素D3、甲状旁腺激素（PTH）及骨源性碱性磷酸酶（BALP）水平。并对血清25-羟维生素D3与HOMA-IR、PTH、BALP进行相关性分析。结果两组TG、LDL-c、HDL-c比较，差异不具有统计学意义（P>0.05）。妊娠晚期糖尿病组FBG、FINS分别为（5.83±0.68）mmol/L、（24.93±2.07）U/L；妊娠晚期健康组FBG、FINS分别为（4.96±0.57）mmol/L、（17.67±1.83）U/L。妊娠晚期糖尿病组FBG、FINS明显高于妊娠晚期健康组，差异具有统计学意义（P<0.05）。妊娠晚期糖尿病组25-羟维生素D3、HOMA-IR、PTH、BALP分别为（24.93±3.23）nmol/L、（0.80±0.08）、（183.69±12.34）ng/L、（30.04±10.23）μg/L；妊娠晚期健康组25-羟维生素D3、HOMA-IR、PTH、BALP 分别为（39.74±5.86）nmol/L、（0.43±0.04）、（165.24±13.07）ng/L、（24.75±9.68）μg/L。两组25-羟维生素D3、HOMA-IR、PTH、BALP比较，差异具有统计学意义（P<0.05）。25-羟维生素D3与HOMA-IR、PTH、BALP均呈负相关关系（r=-0.479，P<0.01；r=-0.283，P<0.05；r=-0.354，P<0.05）。结论妊娠晚期孕妇血清25-羟维生素D3不足，且与胰岛素抵抗呈负相关关系，对骨代谢产生负面影响。
目的：探討妊娠晚期血清25-羥維生素D3對胰島素牴抗、骨代謝的影響。方法以2012年2月~2013年1月到我院接受產前檢查的84例妊娠晚期孕婦為研究對象，根據糖尿病患病情況分為妊娠晚期糖尿病組和妊娠晚期健康組，使用全自動生化分析儀檢測兩組患者的甘油三酯（TG）、低密度脂蛋白膽固醇（LDL-c）、高密度脂蛋白膽固醇（HDL-c）、空腹血糖（FBG）水平。使用自動髮光免疫分析測定空腹胰島素（FINS）、血清25-羥維生素D3、甲狀徬腺激素（PTH）及骨源性堿性燐痠酶（BALP）水平。併對血清25-羥維生素D3與HOMA-IR、PTH、BALP進行相關性分析。結果兩組TG、LDL-c、HDL-c比較，差異不具有統計學意義（P>0.05）。妊娠晚期糖尿病組FBG、FINS分彆為（5.83±0.68）mmol/L、（24.93±2.07）U/L；妊娠晚期健康組FBG、FINS分彆為（4.96±0.57）mmol/L、（17.67±1.83）U/L。妊娠晚期糖尿病組FBG、FINS明顯高于妊娠晚期健康組，差異具有統計學意義（P<0.05）。妊娠晚期糖尿病組25-羥維生素D3、HOMA-IR、PTH、BALP分彆為（24.93±3.23）nmol/L、（0.80±0.08）、（183.69±12.34）ng/L、（30.04±10.23）μg/L；妊娠晚期健康組25-羥維生素D3、HOMA-IR、PTH、BALP 分彆為（39.74±5.86）nmol/L、（0.43±0.04）、（165.24±13.07）ng/L、（24.75±9.68）μg/L。兩組25-羥維生素D3、HOMA-IR、PTH、BALP比較，差異具有統計學意義（P<0.05）。25-羥維生素D3與HOMA-IR、PTH、BALP均呈負相關關繫（r=-0.479，P<0.01；r=-0.283，P<0.05；r=-0.354，P<0.05）。結論妊娠晚期孕婦血清25-羥維生素D3不足，且與胰島素牴抗呈負相關關繫，對骨代謝產生負麵影響。
목적：탐토임신만기혈청25-간유생소D3대이도소저항、골대사적영향。방법이2012년2월~2013년1월도아원접수산전검사적84례임신만기잉부위연구대상，근거당뇨병환병정황분위임신만기당뇨병조화임신만기건강조，사용전자동생화분석의검측량조환자적감유삼지（TG）、저밀도지단백담고순（LDL-c）、고밀도지단백담고순（HDL-c）、공복혈당（FBG）수평。사용자동발광면역분석측정공복이도소（FINS）、혈청25-간유생소D3、갑상방선격소（PTH）급골원성감성린산매（BALP）수평。병대혈청25-간유생소D3여HOMA-IR、PTH、BALP진행상관성분석。결과량조TG、LDL-c、HDL-c비교，차이불구유통계학의의（P>0.05）。임신만기당뇨병조FBG、FINS분별위（5.83±0.68）mmol/L、（24.93±2.07）U/L；임신만기건강조FBG、FINS분별위（4.96±0.57）mmol/L、（17.67±1.83）U/L。임신만기당뇨병조FBG、FINS명현고우임신만기건강조，차이구유통계학의의（P<0.05）。임신만기당뇨병조25-간유생소D3、HOMA-IR、PTH、BALP분별위（24.93±3.23）nmol/L、（0.80±0.08）、（183.69±12.34）ng/L、（30.04±10.23）μg/L；임신만기건강조25-간유생소D3、HOMA-IR、PTH、BALP 분별위（39.74±5.86）nmol/L、（0.43±0.04）、（165.24±13.07）ng/L、（24.75±9.68）μg/L。량조25-간유생소D3、HOMA-IR、PTH、BALP비교，차이구유통계학의의（P<0.05）。25-간유생소D3여HOMA-IR、PTH、BALP균정부상관관계（r=-0.479，P<0.01；r=-0.283，P<0.05；r=-0.354，P<0.05）。결론임신만기잉부혈청25-간유생소D3불족，차여이도소저항정부상관관계，대골대사산생부면영향。
Objective To explore the effects of serum 25-hydroxyl vitamin D3 on insulin resistance and bone metabolism in late pregnancy. Methods A total of 84 women in late pregnancy who received prenatal examination in our hospital from February 2012 to January 2013 were selected as research subjects. They were assigned to diabetes group in late pregnancy and healthy group in late pregnancy according to their physical conditions. TG, LDL-c, HDL-c and FBG levels in the two groups of patients were examined via automatic biochemical analyzer. FINS, serum 25-hy-droxyl vitamin D3, PTH and BALP levels were tested via automated luminescent immunoassay. Correlation analysis was also carried out between serum 25-hydroxyl vitamin and HOMA-IR, PTH and BALP. Results TG, LDL-c and HDL-c were compared between the two groups, and the differences were not statistically significant (P>0.05). FBG and FINS in the diabetes group were (5.83±0.68) mmol/L and (24.93±2.07) U/L respectively; FBG and FINS in the healthy group were (4.96±0.57) mmol/L and (17.67±1.83) U/L respectively. Based on the results above, FBG and FINS in the diabetes group were significantly higher than those in the healthy group, and the differences were statistically significant (P<0.05). 25-hydroxyl vitamin D3, HOMA-IR, PTH and BALP were (24.93±3.23) nmol/L, (0.80±0.08), (183.69±12.34) ng/Land (30.04±10.23) μg/L in diabetes group respectively, while 25-hydroxyl vitamin D3, HOMA-IR, PTH and BALP were (39.74±5.86) nmol/L, (0.43±0.04), (165.24±13.07) ng/L and (24.75±9.68) μg/L in the healthy group respectively. 25-hydroxyl vitamin D3, HOMA-IR, PTH and BALP between the two groups were compared, and the differences were statistically significant (P<0.05). 25-hydroxyl vitamin D3 was negatively correlated with HOMA-IR, PTH and BALP (r=-0.479, P<0.01; r=-0.283, P<0.05; r=-0.354, P<0.05). Conclusion Insufficient serum 25-hydroxyl vitamin D3 in late pregnancy is negatively correlated with insulin resistance and has negative effects on bone metabolism.
