CAJ | 학술논문

目的：观察臭氧水治疗外阴上皮内非瘤样病变的临床疗效。方法选择2010年1月~2013年10月我院妇科门诊收治的外阴上皮内非瘤样病变患者120例[其中鳞状上皮增生（SH）61例、硬化性苔癣/硬化性苔癣合并鳞状上皮增生（LS/LSCSH）59例]，分为臭氧水治疗组90例和药物治疗组（对照组）30例，观察比较两组治疗3个月、6个月有效率及两组复发率和随访情况。结果治疗3个月、6个月臭氧水治疗组每种病理类型有效率及总有效率均明显高于对照组，差异有统计学意义（P<0.05）；臭氧水治疗SH优于治疗LS/LSCSH（P<0.05）；臭氧水治疗组每种病理类型复发率及总复发率均低于对照组，差异有统计学意义（P<0.05）。臭氧水治疗组SH复发率与LS/LSCSH比较，差异无统计学意义（P>0.05）。所有患者臭氧水治疗中及治疗后未见不良事件发生。结论臭氧水治疗SH和LS/LSCSH优于传统药物，为外阴上皮内非瘤样病变的治疗开创了一种新的选择，值得临床推广应用。
목적：관찰취양수치료외음상피내비류양병변적림상료효。방법선택2010년1월~2013년10월아원부과문진수치적외음상피내비류양병변환자120례[기중린상상피증생（SH）61례、경화성태선/경화성태선합병린상상피증생（LS/LSCSH）59례]，분위취양수치료조90례화약물치료조（대조조）30례，관찰비교량조치료3개월、6개월유효솔급량조복발솔화수방정황。결과치료3개월、6개월취양수치료조매충병리류형유효솔급총유효솔균명현고우대조조，차이유통계학의의（P<0.05）；취양수치료SH우우치료LS/LSCSH（P<0.05）；취양수치료조매충병리류형복발솔급총복발솔균저우대조조，차이유통계학의의（P<0.05）。취양수치료조SH복발솔여LS/LSCSH비교，차이무통계학의의（P>0.05）。소유환자취양수치료중급치료후미견불량사건발생。결론취양수치료SH화LS/LSCSH우우전통약물，위외음상피내비류양병변적치료개창료일충신적선택，치득림상추엄응용。
Objective To observe the clinical efficacy of ozone water in treatment of nonneoplastic epithelial disorders of vulva(NEDV). Methods From January 2010 to October 2013, a total of 120 patients with NEDV admitted to depart-ment of gynecology of the Fifth Affiliated Hospital of Xinjiang Medical University [61 cases of squamous hyperplasia (SH), while 59 cases of lichen sclerosus/lichen sclerosus complexed with squamous hyperplasia(LS/LSCSH)] were divided randomly into ozone water treatment group (n=90) and drug treatment group (control group, n=30). Effects of two groups in three months and in six months of treatment and relapse rates and follow-up cases of two groups were compared and observed. Results Effect of each pathological type and the total effective rate of ozone water treatment group in three months and in six months of treatment all were significantly higher than those of control group, the difference was sig-nificant (P<0.05). Ozone water treating SH was superior than treating LS/LSCSH (P<0.05). Recurrence rate of each pathological type of and the overall recurrence rate of ozone water treatment group were lower than those of the control group, the difference was significant (P<0.05). There were no significant differences between SH and LS/LSCSH in recur-rence rate of ozone water treatment group (P>0.05). No adverse events were occurred in all patients treated by ozone water. Conclusion Ozone water that is superior to traditional medicines, can effectively treat SH and LS/LSCSH, be-comes a new treatment for NEDV, worthly clinical application.