CAJ | 학술논문

儿童哮喘的发病率逐年上升.基于卫生假说,抗生素使用可能减少了微生物暴露,从而增加了过敏性疾病发生的风险.近十年来,就早期抗生素暴露与儿童哮喘的关系进行的大量的流行病学调查的结果并不一致.大多数回顾性研究发现正相关联系,但前瞻性研究未发现联系或联系强度较弱.逆向因果和指示混淆可部分解释两者的关系,但也难以否定因果关系的存在.
인동효천적발병솔축년상승.기우위생가설,항생소사용가능감소료미생물폭로,종이증가료과민성질병발생적풍험.근십년래,취조기항생소폭로여인동효천적관계진행적대량적류행병학조사적결과병불일치.대다수회고성연구발현정상관련계,단전첨성연구미발현련계혹련계강도교약.역향인과화지시혼효가부분해석량자적관계,단야난이부정인과관계적존재.
The prevalence of childhood asthma has been increased yearly.Based on the hygiene hypothesis,the antibiotic use may increase the risk of the allergic disease by reducing microbial exposure.In the last decade,a number of epidemiological studies have been conducted on the association between early exposure of antibiotic and childhood asthma,and the results are not consistent.The majority retrospective studies have found a positive association but the prospective studies have showed a null or weak association.Reverse causation and confounding-by-indication may partly explain the relation.But it is difficult to deny a causal link between antibiotic use and asthma.