CAJ | 학술논문

白血病是多基因参与的造血系统恶性增殖性疾病,白血病相关致病基因及基因治疗是目前研究的热点.SOX4基因是SOX C亚族的成员之一,在肺癌、乳腺癌、肝癌、胃癌、髓母细胞瘤等多种人体肿瘤的发生、发展中起重要作用.近年来研究发现,SOX4基因对白血病的发生、治疗及预后评估均有重要意义.该文就SOX4的结构和功能、在白血病中的表达、作用机制以及对白血病治疗和预后的影响等方面作一综述.
백혈병시다기인삼여적조혈계통악성증식성질병,백혈병상관치병기인급기인치료시목전연구적열점.SOX4기인시SOX C아족적성원지일,재폐암、유선암、간암、위암、수모세포류등다충인체종류적발생、발전중기중요작용.근년래연구발현,SOX4기인대백혈병적발생、치료급예후평고균유중요의의.해문취SOX4적결구화공능、재백혈병중적표체、작용궤제이급대백혈병치료화예후적영향등방면작일종술.
Leukemia is a polygenic malignant proliferative disease in the hematopoietic system.Its possible causative genes and gene therapy are one hotspot of the current researches.Sex-determining region Y-related high-mobility-group box transcription factor 4(SOX4) is a member of the group C subfamily of the SOX transcription factors,playing a critical role in the occurrence and development of many tumors such as lung cancer,breast cancer,hepatic carcinoma,gastric cancer and medulloblastoma.Recently,researches have found that SOX4 is significant in the occurrence,treatment and prognosis evaluation of leukemia.This paper reviews the structure and functions of SOX4,its expression and mechanism in leukemia,and its influence on leukemia treatment and prognosis.