国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2015年
2期
159-162
,共4页
急性髓系白血病%化疗方案%靶向治疗%儿童
急性髓繫白血病%化療方案%靶嚮治療%兒童
급성수계백혈병%화료방안%파향치료%인동
Acute myeloid leukemia%Chemotherapeutic regimen%Targeted therapy%Children
急性髓系白血病(acute myeloid leukemia,AML)是一组异质性疾病,约占15岁以下儿童所有确诊肿瘤的15％～ 20％,在过去的几十年里,儿童AML的长期预后取得了巨大的进展.基于AML临床和生物学特征的更加完善的危险度分层,抗白血病药物更加有效的应用以及在支持治疗方面的进展使得儿童AML治愈的可能性达到了60％左右.该文就儿童AML在化疗方案和化疗药物方面的新进展作一综述.
急性髓繫白血病(acute myeloid leukemia,AML)是一組異質性疾病,約佔15歲以下兒童所有確診腫瘤的15％～ 20％,在過去的幾十年裏,兒童AML的長期預後取得瞭巨大的進展.基于AML臨床和生物學特徵的更加完善的危險度分層,抗白血病藥物更加有效的應用以及在支持治療方麵的進展使得兒童AML治愈的可能性達到瞭60％左右.該文就兒童AML在化療方案和化療藥物方麵的新進展作一綜述.
급성수계백혈병(acute myeloid leukemia,AML)시일조이질성질병,약점15세이하인동소유학진종류적15％～ 20％,재과거적궤십년리,인동AML적장기예후취득료거대적진전.기우AML림상화생물학특정적경가완선적위험도분층,항백혈병약물경가유효적응용이급재지지치료방면적진전사득인동AML치유적가능성체도료60％좌우.해문취인동AML재화료방안화화료약물방면적신진전작일종술.
Acute myeloid leukemia(AML) is a heterogeneous kind of disease,which is accounting for 15％ ～ 20％ of all tumors diagnosed in children under 15 years of age.In the past few decades,remarkable improvements have been yielded in long-term outcomes for children with AML.A better risk-group stratification of disease,which is based on clinical and biological features,a more effective use of anti-leukemia agents and enormous improvements in supportive care have increased the rate of cure by approximately 60％.This paper review the new improvements in the chemotherapeutic regimens and drugs.
