CAJ | 학술논문

新生儿化脓性脑膜炎是一种危重的中枢神经系统感染性疾病.大肠杆菌K1菌株(Escherichia coli K1,Ecoli K1)是常见的导致新生儿化脓性脑膜炎的革兰阴性菌,大部分大肠杆菌脑膜炎是血源性传播所导致,其穿过血脑屏障(blood-brain barrier,BBB)的机制一直是研究的重点.相关研究表明,Ecoli K1穿越BBB与高水平菌血症、对脑微血管内皮细胞的侵袭、受体介导的胞吞转运、活菌穿越BBB密切相关.该文从上述四个方面对E.coli K1穿过BBB进入大脑引起新生儿化脓性脑膜炎的发病机制进行综述.
신생인화농성뇌막염시일충위중적중추신경계통감염성질병.대장간균K1균주(Escherichia coli K1,Ecoli K1)시상견적도치신생인화농성뇌막염적혁란음성균,대부분대장간균뇌막염시혈원성전파소도치,기천과혈뇌병장(blood-brain barrier,BBB)적궤제일직시연구적중점.상관연구표명,Ecoli K1천월BBB여고수평균혈증、대뇌미혈관내피세포적침습、수체개도적포탄전운、활균천월BBB밀절상관.해문종상술사개방면대E.coli K1천과BBB진입대뇌인기신생인화농성뇌막염적발병궤제진행종술.
Neonatal purulent meningitis is one of the severe infectious diseases of the central nervous system.Escherichia coli K1 (E.coli K1) strain is the most common Gram-negative bacteria which leads to neonatal purulent meningitis.The mechanism of E.coli K1 translocation of the blood-brain barrier(BBB) include the high degree of bacteremia,invasion of brain microvessel endothelia cell by E.coli K1,receptor-mediated pinocytosis transport for E.coli K1 and the living bacteria across the BBB.The current knowledge on the mechanisms underlying the successful E.coli K1 translocation of the BBB are summarized in this review.