国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2015年
2期
185-189
,共5页
1型糖尿病%嗜铬粒蛋白%胰岛淀粉样多肽%锌转运体8%胰-十二指肠同源盒因子1
1型糖尿病%嗜鉻粒蛋白%胰島澱粉樣多肽%鋅轉運體8%胰-十二指腸同源盒因子1
1형당뇨병%기락립단백%이도정분양다태%자전운체8%이-십이지장동원합인자1
Type 1 diabetes%Chromogranin A%Islet amyloid polypeptide%Zinc transporter 8%Pancreatic duodenal homeobox factor-1
自身免疫是1型糖尿病发病的重要机制.1型糖尿病自身抗原的发现为疾病的发病机制及临床诊治开拓了视野.胰岛素、谷氨酸脱羧酶65、胰岛细胞瘤相关抗原2等是已发现的1型糖尿病主要的自身抗原.近年来,1型糖尿病自身抗原如嗜铬粒蛋白A、胰岛淀粉样多肽、锌转运体8、胰-十二指肠同源盒因子1备受重视.该文就1型糖尿病自身抗原的研究进展进行综述.
自身免疫是1型糖尿病髮病的重要機製.1型糖尿病自身抗原的髮現為疾病的髮病機製及臨床診治開拓瞭視野.胰島素、穀氨痠脫羧酶65、胰島細胞瘤相關抗原2等是已髮現的1型糖尿病主要的自身抗原.近年來,1型糖尿病自身抗原如嗜鉻粒蛋白A、胰島澱粉樣多肽、鋅轉運體8、胰-十二指腸同源盒因子1備受重視.該文就1型糖尿病自身抗原的研究進展進行綜述.
자신면역시1형당뇨병발병적중요궤제.1형당뇨병자신항원적발현위질병적발병궤제급림상진치개탁료시야.이도소、곡안산탈최매65、이도세포류상관항원2등시이발현적1형당뇨병주요적자신항원.근년래,1형당뇨병자신항원여기락립단백A、이도정분양다태、자전운체8、이-십이지장동원합인자1비수중시.해문취1형당뇨병자신항원적연구진전진행종술.
Autoimmunity is the main mechanism of type 1 diabetes.The discovery of autoantigens has broadened our understanding of pathogenesis and clinical diagnosis of type 1 diabetes.Insulin,glutamic acid decarboxylase 65,and insulinoma-associated protein 2 have been found to be major autoantigens of type 1 diabetes.In recent years,some autoantigens in type 1 diabetes,such as chromogranin A,islet amyloid polypeptide,zinc transporter 8,and pancreatic duodenal homeobox factor-1,have received some attention in the literature.The purpose of this article is to review the progress of novel autoantigens in type 1 diabetes.
