CAJ | 학술논문

目的：：检测类风湿关节炎( rheumatoid arthritis, RA)患者血浆同型半胱氨酸(homocysteine, Hcy)及D-二聚体(D-Dimer, DD)水平,探讨其在RA中的临床意义。方法：选择RA患者56例,正常对照组40例,测定其血浆Hcy水平及DD水平并对结果比较分析,同时比较两组CRP水平。结果：淤血浆Hcy和DD水平：RA患者组明显高于健康对照组；于相关性分析显示,RA患者组血浆Hcy和DD水平与DAS28评分均为正相关(r=0.28,P=0.02)和(r=0.36,P=0.01)；盂RA患者组经治疗病情缓解后(DAS28<2.6)血浆Hcy和DD水平显著低于治疗前,与正常对照组比较无统计学意义。结论：血浆Hcy水平、DD水平与RA患者的病情活动有关,可反映心血管病变危险性,对RA患者的病情判断及预后估计有重要意义。
목적：：검측류풍습관절염( rheumatoid arthritis, RA)환자혈장동형반광안산(homocysteine, Hcy)급D-이취체(D-Dimer, DD)수평,탐토기재RA중적림상의의。방법：선택RA환자56례,정상대조조40례,측정기혈장Hcy수평급DD수평병대결과비교분석,동시비교량조CRP수평。결과：어혈장Hcy화DD수평：RA환자조명현고우건강대조조；우상관성분석현시,RA환자조혈장Hcy화DD수평여DAS28평분균위정상관(r=0.28,P=0.02)화(r=0.36,P=0.01)；우RA환자조경치료병정완해후(DAS28<2.6)혈장Hcy화DD수평현저저우치료전,여정상대조조비교무통계학의의。결론：혈장Hcy수평、DD수평여RA환자적병정활동유관,가반영심혈관병변위험성,대RA환자적병정판단급예후고계유중요의의。
ObjectiveTo detect the levels of homocysteine and D-Dimer in the plasma in patients with rheumatoid arthritis (RA), and to investigate its clinical significances in RA. Methods: Blood samples were obtained from 56 patients with RA and 40 cases of the control group. Plasma Hcy, DD and CRP levels of the two groups were determined and compared. Results: ①The titer of Hcy and DD in RA patients was higher than that of the control group.②There was correlation between DAS28 and Hcy, DD[(r = 0.28,P= 0.02)and(r = 0.36,P=0.01)]. ③The titer of both Hcy and DD in RA patients after treatments were lower than that of patients before treatments. And there was no difference between RA patients (DAS28 < 2.60) and the control group. Conclusion: The titer of Hcy and DD in the plasma of RA patients was correlated with disease activities. This titer can reflect the risk of cardiovascular disease, and judge RA patient's symptomatic change and prognosis.