CAJ | 학술논문

目的：探讨盐酸法舒地尔注射液治疗短暂性脑缺血发作的临床疗效和安全性。方法短暂性脑缺血发作患者123例，随机分为治疗组62例和对照组61例；治疗组用盐酸法舒地尔注射液30 mg加入0．9％氯化钠注射液250 ml静脉滴注，1次／日，共7天；对照组用0．9％氯化钠注射液250 ml静脉滴注，1次／日，共7天；两组均予阿司匹林、阿托他汀等常规治疗。治疗前、治疗后分别检查全血粘度、血浆粘度和红细胞聚集。结果治疗组总有效率96．77％，对照组总有效率88．52％，两组总有效率有统计学意义（ P＜0．05）。治疗后，治疗组全血粘度、血浆粘度和红细胞聚集明显降低，与对照组比较有统计学意义（ P＜0．05）。结论盐酸法舒地尔对刺激神经功能的恢复，改善局限性脑功能缺失临床症状，有很好疗效。
목적：탐토염산법서지이주사액치료단잠성뇌결혈발작적림상료효화안전성。방법단잠성뇌결혈발작환자123례，수궤분위치료조62례화대조조61례；치료조용염산법서지이주사액30 mg가입0．9％록화납주사액250 ml정맥적주，1차／일，공7천；대조조용0．9％록화납주사액250 ml정맥적주，1차／일，공7천；량조균여아사필림、아탁타정등상규치료。치료전、치료후분별검사전혈점도、혈장점도화홍세포취집。결과치료조총유효솔96．77％，대조조총유효솔88．52％，량조총유효솔유통계학의의（ P＜0．05）。치료후，치료조전혈점도、혈장점도화홍세포취집명현강저，여대조조비교유통계학의의（ P＜0．05）。결론염산법서지이대자격신경공능적회복，개선국한성뇌공능결실림상증상，유흔호료효。
Objective To investigate the efficacy and safety of Fasudil hydrochloride injection in the treament of transient ischemic attack.Methods 123 patients with transient ischemic attack were randomly divided into two groups.62 cases of the treatment group received intravenous drips of Fasudil hydrochloride injection:30 mg of asudil hydrochloride Injection +250ml of 0.9%Sodium Chloride Injection 1 time /day for 7 days, while 61 cases of the control group received intravenous drip of 250ml of Sodium Chloride Injection 1 time /day for 7 days.Both groups were given conventional treatment such as aspirin, atorvastatin, to observe blood viscosity, plasma viscosity and erythrocyte aggregation before and after the treatment respectively.Results The total effective rate of the control group was 96.77%, significantly higher than 88.52%of the control group, and the difference was statistically significant (P<0.05).After the treatment, the whole blood viscosity, plasma viscosity and erythrocyte aggregation were significantly lower in the treatment group than those in the control group, which was statistically significant (P<0.05).Conclusions Fasudil hydrochloride Injection has a very good curative effect on stimulating the recovery of nerve function and improving deficiency of brain function.