CAJ | 학술논문

目的：慢性疼痛合并抑郁、焦虑障碍住院患者予抗抑郁抗焦虑药物治疗后，观察其治疗效果。方法将56例患者分为两组，分别服用文拉法辛和帕罗西汀治疗。患者治疗前后采用Zung氏抑郁自评量表（ SDS）、焦虑自评量表（ SAS）进行评定。结果连续治疗3周后，两组SAS、SDS评分均下降，但文拉法辛组与帕罗西汀组相比下降程度更为显著（P＜0．01）；且文拉法辛治疗组的临床治疗效果总体评价优于帕罗西汀组（χ2＝8．64，P＜0．05）。结论文拉法辛治疗慢性疼痛伴抑郁、焦虑效果优于帕罗西汀，故可在临床上将文拉法辛进一步推广使用。
목적：만성동통합병억욱、초필장애주원환자여항억욱항초필약물치료후，관찰기치료효과。방법장56례환자분위량조，분별복용문랍법신화파라서정치료。환자치료전후채용Zung씨억욱자평량표（ SDS）、초필자평량표（ SAS）진행평정。결과련속치료3주후，량조SAS、SDS평분균하강，단문랍법신조여파라서정조상비하강정도경위현저（P＜0．01）；차문랍법신치료조적림상치료효과총체평개우우파라서정조（χ2＝8．64，P＜0．05）。결논문랍법신치료만성동통반억욱、초필효과우우파라서정，고가재림상상장문랍법신진일보추엄사용。
Objective After chronic pain inpatients with depression and anxiety disorder were treated with antidepressant and anxiolytic drug, then observed its curative effect.Methods 56 patients were divided into two groups, respectively taking Venlafaxine and Paroxetine therapy.Patients were evaluated by ZUNG's self rating Depression Scale ( SDS) and self rating Anxiety Scale ( SAS) assessment before and after therapy.Results After 3 weeks of continuous treatment, two groups of SAS, SDS scores decreased, but Venlafaxine group decreased more significantly than Paroxetine group( P<0.01); and Venlafaxine group on overall evaluation of clinical treatment effect was better than that of Paroxetine group (χ2 =8.64,P <0.05).Conclusions Venlafaxine in the treatment of chronic pain accompanied by depression and anxiety effect is better than that of Paroxetine, so Venlafaxine should be further promoting used in clinic.