CAJ | 학술논문

目的：探讨美沙拉嗪与枯草杆菌二联活菌肠溶胶囊联合使用对溃疡性结肠炎的治疗效果。方法回顾性分析2013年4月至2014年7月我院收治的溃疡性结肠炎患者129例，按治疗方法分为两组，对照组64例采用美沙拉嗪治疗，观察组65例在对照组治疗基础上加用枯草杆菌二联活菌肠溶胶囊治疗，比较两组患者临床疗效、临床症状积分、不良反应发生情况。结果（1）观察组治疗总有效率（95．38％）与对照组（78．13％）比较明显较高，两组差异有统计学意义（P＜0．05）。（2）观察组和对照组治疗后临床症状积分与治疗前比较均出现明显降低，观察组降低的幅度更大，治疗后的临床症状积分与对照组治疗后比较明显较低，两组差异有统计学意义（P＜0．05）。（3）观察组不良反应发生率（18．46％）与对照组（21．88％）比较差异无统计学意义（P＞0．05）。结论美沙拉嗪颗粒与枯草杆菌二联活菌肠溶胶囊联合治疗溃疡性结肠炎疗效显著，可提高临床总有效率，使患者临床症状体征显著改善，安全性较高，可以临床推广使用。
목적：탐토미사랍진여고초간균이련활균장용효낭연합사용대궤양성결장염적치료효과。방법회고성분석2013년4월지2014년7월아원수치적궤양성결장염환자129례，안치료방법분위량조，대조조64례채용미사랍진치료，관찰조65례재대조조치료기출상가용고초간균이련활균장용효낭치료，비교량조환자림상료효、림상증상적분、불량반응발생정황。결과（1）관찰조치료총유효솔（95．38％）여대조조（78．13％）비교명현교고，량조차이유통계학의의（P＜0．05）。（2）관찰조화대조조치료후림상증상적분여치료전비교균출현명현강저，관찰조강저적폭도경대，치료후적림상증상적분여대조조치료후비교명현교저，량조차이유통계학의의（P＜0．05）。（3）관찰조불량반응발생솔（18．46％）여대조조（21．88％）비교차이무통계학의의（P＞0．05）。결론미사랍진과립여고초간균이련활균장용효낭연합치료궤양성결장염료효현저，가제고림상총유효솔，사환자림상증상체정현저개선，안전성교고，가이림상추엄사용。
Objective To investigate the clinical effect of mesalazine and bacillus subtiliscombinedlive bacteria enteric-coated capsules in the treatment of ulcerative colitis.Methods The datas of 129 cases of patients with ulcerative colitis collected, they received therapy in our hospital during April 2013 and July 2014, were retrospective analyzed.They were divided into two groupsaccording to the treatment method, 64 cases in the control group under the treatment of mesalazine, however, the 65 cases in observation groupwere treated with bacillus subtilis enteric-coated capsuleson the bases of the control group.The clinical efficacy, clinical symptom scores, adverse events of two groups were compared.Results The total effective of the observation group (95.38%) was significantly higher than the control group (78.13%), the difference was statistically significant (P<0.05).The clinical symptoms scores of the observation group and the control group were decreased after the treatment, the reduction in the observation group was larger, and theclinical symptoms scores of the observation group after treatment was lower than the control group after treatment, the difference was statistically significant (P<0.05).There were no significant difference in the incidence of adverse reactions between the observation group (18.46%) and the control group (21.88%)(P>0.05).Conclusions Mesalazine granules and Bacillus subtilis combined live bacteria enteric-coated capsules in the treatment of ulcerative colitis can obtain significant effect, as well as improve the overall clinical efficiency and clinical signs and symptoms, it is high in security,so it can be popularized in clinical use.