CAJ | 학술논문

目的：探讨沙美特罗／氟替卡松治疗慢性阻塞性肺疾病的临床疗效。方法将72例慢性阻塞性肺疾病患者随机分成两组，对照组36例，观察组36例。对照组行常规治疗，观察组在常规治疗基础上给予沙美特罗／氟替卡松粉吸剂治疗。治疗3个月后，比较肺功能参数、呼吸困难评分和临床疗效。结果观察组患者治疗显效率、总有效率均明显高于对照组（P＜0．05）；对照组患者FVC、FEV1、FEV1／FVC％三项肺功能参数治疗后均有所升高，但与治疗前比较无显著性差异（P＞0．05），观察组患者治疗后三项肺功能参数则明显升高（ P＜0．01）；对照组患者治疗后呼吸困难评分有所下降，但与治疗前比较无显著性差异（P＞0．05），观察组患者治疗后呼吸困难评分则明显下降（P＜0．01）。结论沙美特罗／氟替卡松治疗慢性阻塞性肺疾病可产生协同作用，临床疗效显著。
목적：탐토사미특라／불체잡송치료만성조새성폐질병적림상료효。방법장72례만성조새성폐질병환자수궤분성량조，대조조36례，관찰조36례。대조조행상규치료，관찰조재상규치료기출상급여사미특라／불체잡송분흡제치료。치료3개월후，비교폐공능삼수、호흡곤난평분화림상료효。결과관찰조환자치료현효솔、총유효솔균명현고우대조조（P＜0．05）；대조조환자FVC、FEV1、FEV1／FVC％삼항폐공능삼수치료후균유소승고，단여치료전비교무현저성차이（P＞0．05），관찰조환자치료후삼항폐공능삼수칙명현승고（ P＜0．01）；대조조환자치료후호흡곤난평분유소하강，단여치료전비교무현저성차이（P＞0．05），관찰조환자치료후호흡곤난평분칙명현하강（P＜0．01）。결론사미특라／불체잡송치료만성조새성폐질병가산생협동작용，림상료효현저。
Objective To discuss the clinical effect on chronic obstructive pulmonary disease treatment by salmeterol/fluticasone.Methods 72 cases of patients with chronic obstructive pulmonary disease were randomly divided into two groups, including 36 cases in the control group and 36 cases in the observation group. Patients in the control group took conventional treatment, and those in the observation group receive salmeterol /fluticasone powder inhaler therapy on the basis of the conventional treatment.3 months after treatment, lung function parameters, dyspnea score and clinical efficacy of the two groups were compared.Results The efficacy and total effective rate of patients in the observation group were both significantly higher than that in the control group (P<0.05);Three lung function parameters, namely, FVC, FEV1 and FEV1 /FVC%of patients in the control group had increased slightly after treatment with insignificant difference compared with the pre-treatment state (P>0.05), while the lung function parameters of patients in the observation group had been increased greatly after treatment(P<0.01);The dyspnea score for patients in the control group had reduced after treatment but with insignificant difference (P>0.05), while the dyspnea score for patients in the observation group had decreased dramatically ( P <0.01 ).Conclusions Salmeterol/fluticasone treatment of chronic obstructive pulmonary disease can produce a synergistic effect with significant clinical effect.