中华临床免疫和变态反应杂志
中華臨床免疫和變態反應雜誌
중화림상면역화변태반응잡지
CHINESE JOURNAL OF ALLERGY & CLINICAL IMMUNOLOGY
2015年
1期
61-66
,共6页
系统性红斑狼疮%血小板减少%治疗
繫統性紅斑狼瘡%血小闆減少%治療
계통성홍반랑창%혈소판감소%치료
systemic lupus erythematosus%thrombocytopenia%therapy
系统性红斑狼疮患者血小板减少为轻到中度，不需要特别处理；但当出现出血、大血肿或血小板计数＜30×109/L 时，则需要进行治疗。已有报道系统性红斑狼疮相关血小板计数减少的治疗药物和方法包括糖皮质激素、免疫抑制剂、静脉注射免疫球蛋白、羟氯喹、血浆置换、达那唑和脾脏切除，也包括一些新药（利妥昔单抗、促血小板生成素）和其他方法（应用氨苯砜、自体造血干细胞移植）。
繫統性紅斑狼瘡患者血小闆減少為輕到中度，不需要特彆處理；但噹齣現齣血、大血腫或血小闆計數＜30×109/L 時，則需要進行治療。已有報道繫統性紅斑狼瘡相關血小闆計數減少的治療藥物和方法包括糖皮質激素、免疫抑製劑、靜脈註射免疫毬蛋白、羥氯喹、血漿置換、達那唑和脾髒切除，也包括一些新藥（利妥昔單抗、促血小闆生成素）和其他方法（應用氨苯砜、自體造血榦細胞移植）。
계통성홍반랑창환자혈소판감소위경도중도，불수요특별처리；단당출현출혈、대혈종혹혈소판계수＜30×109/L 시，칙수요진행치료。이유보도계통성홍반랑창상관혈소판계수감소적치료약물화방법포괄당피질격소、면역억제제、정맥주사면역구단백、간록규、혈장치환、체나서화비장절제，야포괄일사신약（리타석단항、촉혈소판생성소）화기타방법（응용안분풍、자체조혈간세포이식）。
Thrombocytopenia is a common manifestation of systemic lupus erythematosus.For those patients with mild to moderate thrombocytopenia, no specific treatment is needed. However, when they developed severe thrombocytopenia,ie,platelet level less than 30 ×109 /L,and complicated with hemorrhage,treatments must be initiated.The drugs and measures for thrombocytopenia related to systemic lupus erythematosus included glucocorticoid,immunosuppressive agents,intravenous immunoglobulins,hydroxychloroquine,plasma exchange, danazol,and splenectomy.Some new medicines (rituximab and thrombopoietin)and other methods (dapsone and autologous hematopoietic stem cell transplantation)were tried in the treatments for this situation.In this review, we summarized the current status of the treatments and challenges of severe thrombocytopenia in an evidence-based approach.
