CAJ | 학술논문

目的：探讨奥氮平与利培酮治疗老年期痴呆患者的精神行为症状的疗效及不良反应。方法对70例老年痴呆患者随机分为奥氮平组和利培酮组进行治疗，疗程8周。采用阿尔茨海默病病理行为评定表（ BEHAVE-AD ）及不良反应症状量表（ TESS ）评定疗效和不良反应。结果治疗后两组BEHAV-AD评分均显著下降（P＜0．05或P＜0．01）；4周时以奥氮平组BEHAV-AD总分及行为紊乱、抑郁、焦虑评分降低明显（P＜0．05）；奥氮平组有效率91．43％，利培酮组有效率88．57％（P＞0．05）；在锥体外系反应（EPS）、失眠的发生率利培酮组高于奥氮平组（P＜0．05）。结论奥氮平和利培酮用于治疗阿尔茨海默病精神行为症状的临床疗效相当，但奥氮平的安全性更好。
목적：탐토오담평여리배동치료노년기치태환자적정신행위증상적료효급불량반응。방법대70례노년치태환자수궤분위오담평조화리배동조진행치료，료정8주。채용아이자해묵병병리행위평정표（ BEHAVE-AD ）급불량반응증상량표（ TESS ）평정료효화불량반응。결과치료후량조BEHAV-AD평분균현저하강（P＜0．05혹P＜0．01）；4주시이오담평조BEHAV-AD총분급행위문란、억욱、초필평분강저명현（P＜0．05）；오담평조유효솔91．43％，리배동조유효솔88．57％（P＞0．05）；재추체외계반응（EPS）、실면적발생솔리배동조고우오담평조（P＜0．05）。결론오담평화리배동용우치료아이자해묵병정신행위증상적림상료효상당，단오담평적안전성경호。
Objective To compare the effect and adverse reaction of olanzapine and risperidone in the treatment of behavioral and psychological symptoms of Alzheimer's disease.Methods 70 cases with Alzheimer's disease were randomly divided into 2 groups, being treated with olanzapine and risperidone seperately for 8 weeks.The Alzheimer's disease pathology behavioral assessment scale ( BEHAVE-AD) and Treatment Emergent Symptom Scale ( TESS) were used to assess the efficacy and adverse reactions.Results Scores of BEHAV-AD decreased significantly after treatment (P<0.05 or P<0.01).4 weeks after treatment, total scores of BEHAV-AD and behavior disorders, depression, anxiety scores were significantly decreased (P<0.05).The effective rate in olanzapine group and risperidone group were 91.43%and 88.57%separately (P>0.05).The incidence of extrapyramidal system reaction ( EPS) and insomnia in risperidone group was higher than that of olanzapine group (P <0.05).Conclusions Olanzapine and risperidone had considerable effect in the treatment of behavioral and psychological symptoms of Alzheimer's disease, but olanzapine had better safety.