CAJ | 학술논문

目的：探讨新辅助化疗治疗晚期子宫内膜癌的临床效果。方法80例晚期子宫内膜癌患者随机分为观察组和对照组，各40例。观察组患者给予顺铂＋紫杉醇方案的新辅助化疗4个疗程；对照组患者手术后进行相同方案的化疗。结果观察组的化疗总有效率为75．0％，明显高于对照组的52．5％，差异有统计学意义（P＜0．05）。观察组的胃肠道反应和骨髓抑制的发生率，以及毒副作用的总发生率，均显著低于对照组（ P＜0．05）。结论与常规术后化疗比较，新辅助化疗治疗晚期子宫内膜癌的近期疗效显著，且毒副作用发生率较低，但仍需进行大样本的研究进一步明确其价值。
목적：탐토신보조화료치료만기자궁내막암적림상효과。방법80례만기자궁내막암환자수궤분위관찰조화대조조，각40례。관찰조환자급여순박＋자삼순방안적신보조화료4개료정；대조조환자수술후진행상동방안적화료。결과관찰조적화료총유효솔위75．0％，명현고우대조조적52．5％，차이유통계학의의（P＜0．05）。관찰조적위장도반응화골수억제적발생솔，이급독부작용적총발생솔，균현저저우대조조（ P＜0．05）。결론여상규술후화료비교，신보조화료치료만기자궁내막암적근기료효현저，차독부작용발생솔교저，단잉수진행대양본적연구진일보명학기개치。
Objective This paper as to investigate the clinical effect of neoadjuvant chemotherapy in the treatmentofadvancedendometrialcancer.Methods 80patientswithadvancedendometrialcancerwererandomly divided into observation group and control group, 40 in each group.Patients in observation group were treated with cisplatin and paclitaxel regimen for 4 courses during preoperative period and patients in control group were treated with same regimen during postoperative period.Results The total short-term effective rate of observation group was 75.0%, which was significantly higher than 52.5% in control group, the difference was statistically significant (P<0.05).The incidence of gastrointestinal reaction, myelo suppression and the total rate of toxicity in observation group was significantly lower than those of control group (P<0.05).Conclusions Compared with conventional postoperative chemotherapy, short-term effect of neoadjuvant chemotherapy is significant higher and has lower toxicity in treating advanced endometrial carcinoma, but further studies with larger sample size are still needed to define its value.