齐齐哈尔医学院学报
齊齊哈爾醫學院學報
제제합이의학원학보
JOURNAL OF QIQIHAR MEDICAL COLLEGE
2015年
11期
1578-1579
,共2页
血清胱抑素C%尿微量白蛋白肌酐比%高血压患者%早期肾损害
血清胱抑素C%尿微量白蛋白肌酐比%高血壓患者%早期腎損害
혈청광억소C%뇨미량백단백기항비%고혈압환자%조기신손해
Serum cystatin C%Urinary albumin-creatinine ratio%Hypertensive patients%Early renal damage
目的探讨血清胱抑素C和尿微量白蛋白肌酐比在高血压患者早期肾损害筛查中的应用价值。方法选择尿蛋白阴性的80例原发性高血压患者为高血压组，60例正常健康人为健康对照组。采用免疫投射比浊法检测两组患者的血清胱抑素C （ CysC ）含量；免疫浊度法检测尿微量白蛋白含量（mAlb）；全自动生活分析仪检测尿肌酐含量（Cr），并计算尿微量白蛋白肌酐比（尿mAlb／Cr）。结果高血压组患者血CysC含量和尿mAlb／Cr都明显高于对照组（P＜0．05）；血CysC和尿mAlb／Cr联合检测检出率为75．0％明显高于血CysC的60．0％和尿mAlb／Cr的62．5％（ P＜0．05）；血CysC和尿mAlb／Cr联合检测的灵敏度为75．0％、特异性为91．7％、假阳性率为8．3％、假阴性率为25．0％、诊断符合度为82．1％。结论血CysC和尿mAlb／Cr联合检测法对高血压早期肾损害患者具有较高的诊断价值。
目的探討血清胱抑素C和尿微量白蛋白肌酐比在高血壓患者早期腎損害篩查中的應用價值。方法選擇尿蛋白陰性的80例原髮性高血壓患者為高血壓組，60例正常健康人為健康對照組。採用免疫投射比濁法檢測兩組患者的血清胱抑素C （ CysC ）含量；免疫濁度法檢測尿微量白蛋白含量（mAlb）；全自動生活分析儀檢測尿肌酐含量（Cr），併計算尿微量白蛋白肌酐比（尿mAlb／Cr）。結果高血壓組患者血CysC含量和尿mAlb／Cr都明顯高于對照組（P＜0．05）；血CysC和尿mAlb／Cr聯閤檢測檢齣率為75．0％明顯高于血CysC的60．0％和尿mAlb／Cr的62．5％（ P＜0．05）；血CysC和尿mAlb／Cr聯閤檢測的靈敏度為75．0％、特異性為91．7％、假暘性率為8．3％、假陰性率為25．0％、診斷符閤度為82．1％。結論血CysC和尿mAlb／Cr聯閤檢測法對高血壓早期腎損害患者具有較高的診斷價值。
목적탐토혈청광억소C화뇨미량백단백기항비재고혈압환자조기신손해사사중적응용개치。방법선택뇨단백음성적80례원발성고혈압환자위고혈압조，60례정상건강인위건강대조조。채용면역투사비탁법검측량조환자적혈청광억소C （ CysC ）함량；면역탁도법검측뇨미량백단백함량（mAlb）；전자동생활분석의검측뇨기항함량（Cr），병계산뇨미량백단백기항비（뇨mAlb／Cr）。결과고혈압조환자혈CysC함량화뇨mAlb／Cr도명현고우대조조（P＜0．05）；혈CysC화뇨mAlb／Cr연합검측검출솔위75．0％명현고우혈CysC적60．0％화뇨mAlb／Cr적62．5％（ P＜0．05）；혈CysC화뇨mAlb／Cr연합검측적령민도위75．0％、특이성위91．7％、가양성솔위8．3％、가음성솔위25．0％、진단부합도위82．1％。결론혈CysC화뇨mAlb／Cr연합검측법대고혈압조기신손해환자구유교고적진단개치。
Objective This paper was to investigate value of serum cystatin C and urinary albumin-creatinine ratio in early renal damage screening for hypertension patients.Methods 80 cases of essential hypertension patients with urinary protein-negative were selected as hypertension group, and 60 cases of healthy people were selected as control group.The serum cystatin C ( CysC ) levels of two groups were detected by immune projection nephelometry method, urinary albumin content ( mAlb) levels of two groups were detected by immune turbidity method.Urine creatinine ( Cr ) levels of two groups were detected by automatic biochemical analyzer.And the urinary albumin-creatinine ratio ( mAlb /Cr) of two groups were calculated.Results Urine CysC and mAlb/Cr levels of hypertensive group were significantly higher control group (P<0.05).The detection rate of Urine CysC combined mAlb/Cr was 75.0%, which was significantly higher than CysC ( 60.0%) and mAlb/Cr 62.5%(P<0.05).For Urine CysC combined mAlb/Cr, the sensitivity was 75.0%, specificity was 91.7%, false positive rate was 8.3%, the false negative rate was 25.0%, diagnose compliance was 82.1%. Conclusions Urine CysC combined mAlb/Cr has high value in early renal damage detection for hypertension patients.
