CAJ | 학술논문

目的：探讨左卡尼汀对血液透析患者营养状态及贫血的影响。方法回顾性分析我院2012年4月至2014年8月收治的60例血液透析患者临床资料，按是否给予左卡尼汀分为观察组和对照组，对照组常规透析、改善贫血等治疗，观察组是在对照组基础上，血液透析后观察组给予1．0 g左卡尼汀静脉注射，治疗3个月后比较两组患者贫血和营养状态。结果经过治疗后观察组患者Hb、Alb和Hct水平均较对照组高，差异有统计学意义（P＜0．05）。治疗前两组患者TC、TG和BUN水平比较差异均无统计学意义（P＞0．05），经过治疗后观察组BUN明显增高，TG明显降低，与对照组比较差异有统计学意义（P＜0．05）。两组患者不良反应发生率比较差异无统计学意义（χ2＝1．418，P＞0．05）。结论左卡尼汀可有效改善血液透析患者的贫血及营养状态，应在血液透析的临床应用中广泛采用。
목적：탐토좌잡니정대혈액투석환자영양상태급빈혈적영향。방법회고성분석아원2012년4월지2014년8월수치적60례혈액투석환자림상자료，안시부급여좌잡니정분위관찰조화대조조，대조조상규투석、개선빈혈등치료，관찰조시재대조조기출상，혈액투석후관찰조급여1．0 g좌잡니정정맥주사，치료3개월후비교량조환자빈혈화영양상태。결과경과치료후관찰조환자Hb、Alb화Hct수평균교대조조고，차이유통계학의의（P＜0．05）。치료전량조환자TC、TG화BUN수평비교차이균무통계학의의（P＞0．05），경과치료후관찰조BUN명현증고，TG명현강저，여대조조비교차이유통계학의의（P＜0．05）。량조환자불량반응발생솔비교차이무통계학의의（χ2＝1．418，P＞0．05）。결론좌잡니정가유효개선혈액투석환자적빈혈급영양상태，응재혈액투석적림상응용중엄범채용。
Objective This paper was to evaluate the application effect of L-carnitine on nutritional status and anemia inmaintenance hemodialysis patients.Methods A retrospective analysis was made on 60 cases of maintenance hemodialysispatients who received treatment in our hospital during April 2012and August 2014, they were divided into experimental group and control group according to whethergiven l-carnitine.Patients in control group were treated with same volume of salineand patients in the experimental group were treated with l-carnitine,nutritional status and anemia of the two groups after the treatment for 3 monthswere compared.Results After the treatment,the levels of Hb,Hct and Alb of experimental group were higher than that of control group, differences were statistically significant ( P <0.05 ) .Differences of TC, TG and BUN between two had no statistically significant ( P >0.05 ).The concentration of BUN of experimental group increasedand TG concentration decreased after the treatment,there were statistically significantdifferences between the two groups (P<0.05).Difference of adverse reaction rate between the two groups had no statisticallysignificant (χ2 =1. 418,P >0.05).Conclusions L -carnitine could improve nutritional status and anemia of maintenance hemodialysispatients,it should be widely used in maintenance hemodialysis.