心脑血管病防治
心腦血管病防治
심뇌혈관병방치
PREVENTION AND TREATMENT OF CARDIO-CEREBRAL-VASCULAR DISEASE
2015年
2期
107-109
,共3页
持续性心房颤动%缬沙坦%高血压%炎症因子%左心房内径
持續性心房顫動%纈沙坦%高血壓%炎癥因子%左心房內徑
지속성심방전동%힐사탄%고혈압%염증인자%좌심방내경
Persistent atrial fibrillation%Valsartan%Hypertension%Inflammatory factors%Left atrial diameter
目的：探讨缬沙坦对老年高血压合并持续性心房颤动患者炎症因子表达水平及左心房内径的影响。方法将125例高血压病持续性心房颤动的老年患者随机分成缬沙坦组（65例）和对照组（60例），在常规抗心律失常、抗凝药物治疗基础上，缬沙坦组给予缬沙坦降压治疗，对照组予以硝苯地平降压治疗。6个月后比较两组患者治疗前后血清炎症因子（CRP、TNF_α、IL_6和AngⅡ）水平及左心房内径（LAD ）变化。结果两组患者基础临床资料差异无统计学意义（ P＞0.05）。6个月后，与同组治疗前及对照组治疗后比较，缬沙坦组患者血清CRP、TNF_α、IL_6和AngⅡ水平明显下降、LAD显著缩小，差异均有统计学意义（均 P＜0.05）。结论缬沙坦可降低老年高血压患者合并持续性心房颤动时的炎症反应，改善心房重构，以减少心房颤动的发生和维持。
目的：探討纈沙坦對老年高血壓閤併持續性心房顫動患者炎癥因子錶達水平及左心房內徑的影響。方法將125例高血壓病持續性心房顫動的老年患者隨機分成纈沙坦組（65例）和對照組（60例），在常規抗心律失常、抗凝藥物治療基礎上，纈沙坦組給予纈沙坦降壓治療，對照組予以硝苯地平降壓治療。6箇月後比較兩組患者治療前後血清炎癥因子（CRP、TNF_α、IL_6和AngⅡ）水平及左心房內徑（LAD ）變化。結果兩組患者基礎臨床資料差異無統計學意義（ P＞0.05）。6箇月後，與同組治療前及對照組治療後比較，纈沙坦組患者血清CRP、TNF_α、IL_6和AngⅡ水平明顯下降、LAD顯著縮小，差異均有統計學意義（均 P＜0.05）。結論纈沙坦可降低老年高血壓患者閤併持續性心房顫動時的炎癥反應，改善心房重構，以減少心房顫動的髮生和維持。
목적：탐토힐사탄대노년고혈압합병지속성심방전동환자염증인자표체수평급좌심방내경적영향。방법장125례고혈압병지속성심방전동적노년환자수궤분성힐사탄조（65례）화대조조（60례），재상규항심률실상、항응약물치료기출상，힐사탄조급여힐사탄강압치료，대조조여이초분지평강압치료。6개월후비교량조환자치료전후혈청염증인자（CRP、TNF_α、IL_6화AngⅡ）수평급좌심방내경（LAD ）변화。결과량조환자기출림상자료차이무통계학의의（ P＞0.05）。6개월후，여동조치료전급대조조치료후비교，힐사탄조환자혈청CRP、TNF_α、IL_6화AngⅡ수평명현하강、LAD현저축소，차이균유통계학의의（균 P＜0.05）。결론힐사탄가강저노년고혈압환자합병지속성심방전동시적염증반응，개선심방중구，이감소심방전동적발생화유지。
Objective To investigate the effects of valsartan on levels of inflammatory factors and left atrial diameter (LAD) in the el-derly patients with hypertension complicated persistent atrial fibrillation. Methods 125 elderly patients with hypertension complicated with persistent atrial fibrillation were randomly divided into valsartan group (65 cases) and control group (60 cases).On top of con-ventional anti_arrhythmic and anti_coagulant therapy ,valsartan and nifedipine controlled releases tablets were used for antihypertensive therapy in valsartan group and control group respectively.After 6 months’ treatment ,the levels of inflammatory factors ,including C_reactive protein (CRP ) ,Interleukin_6 (IL_6 ) ,tumor necrosis factor_α(TNF_α) ,angiotensin (AngⅡ) ,and the LAD variation of left atrium for both groups were compared.Results Before treatment ,there was no significant difference between two groups ( P>0.05 ) . Compared with that before treatment and control group after treatment ,the serum levels of CRP ,IL_6 ,TNF_αand AngⅡin valsartan group were significantly decreased and LAD was obviously decreased after 6 months (all P<0.05).Conclusions There is an inde-pendent anti_inflammatory effect of valsartan on elderly patients with hypertension complicated persistent atrial fibrillation ,decreasing inflammatory reaction can improve atrial remodeling and reduce the occurrence and maintenance of AF.
