心脑血管病防治
心腦血管病防治
심뇌혈관병방치
PREVENTION AND TREATMENT OF CARDIO-CEREBRAL-VASCULAR DISEASE
2015年
2期
101-103
,共3页
高血压%胱抑素C%左心室肥厚%心功能%脑钠肽
高血壓%胱抑素C%左心室肥厚%心功能%腦鈉肽
고혈압%광억소C%좌심실비후%심공능%뇌납태
Hypertension%Cystatin C%Left ventricular hypertrophy%Heart function%Brain natriuretic peptide
目的：分析高龄高血压患者血清胱抑素C （CysC ）水平与左心室肥厚及心功能的相关性。方法将110例高龄高血压患者根据左心室质量、NYHA心功能分级分为左心室肥厚组（LVH组）与非肥厚组（非LVH组），比较两组血清CysC水平及与心功能之间的相关性。结果 LVH组CysC水平较非LVH组明显升高，差异有统计学意义（ P＜0.01）。血清CysC水平与左心室舒张末期内径（LVDD）、室间隔厚度（IVS）、左心室后壁厚度（LVPW）及左心室质量指数（LVMI）呈正相关（r＝0.27～0.35，P＜0.01）。CysC与射血分数（EF）值负相关（r＝－0.39，P＜0.01），与脑钠肽（BNP）水平呈正相关（ r＝0.29，P＜0.01）。CysC水平与心功能分级间呈正相关（ r＝0.56，P＜0.01）。结论高龄高血压患者血清CysC水平与左心室肥厚及心功能密切相关，可作为反映左心室肥厚程度及心功能分级的重要指标之一。
目的：分析高齡高血壓患者血清胱抑素C （CysC ）水平與左心室肥厚及心功能的相關性。方法將110例高齡高血壓患者根據左心室質量、NYHA心功能分級分為左心室肥厚組（LVH組）與非肥厚組（非LVH組），比較兩組血清CysC水平及與心功能之間的相關性。結果 LVH組CysC水平較非LVH組明顯升高，差異有統計學意義（ P＜0.01）。血清CysC水平與左心室舒張末期內徑（LVDD）、室間隔厚度（IVS）、左心室後壁厚度（LVPW）及左心室質量指數（LVMI）呈正相關（r＝0.27～0.35，P＜0.01）。CysC與射血分數（EF）值負相關（r＝－0.39，P＜0.01），與腦鈉肽（BNP）水平呈正相關（ r＝0.29，P＜0.01）。CysC水平與心功能分級間呈正相關（ r＝0.56，P＜0.01）。結論高齡高血壓患者血清CysC水平與左心室肥厚及心功能密切相關，可作為反映左心室肥厚程度及心功能分級的重要指標之一。
목적：분석고령고혈압환자혈청광억소C （CysC ）수평여좌심실비후급심공능적상관성。방법장110례고령고혈압환자근거좌심실질량、NYHA심공능분급분위좌심실비후조（LVH조）여비비후조（비LVH조），비교량조혈청CysC수평급여심공능지간적상관성。결과 LVH조CysC수평교비LVH조명현승고，차이유통계학의의（ P＜0.01）。혈청CysC수평여좌심실서장말기내경（LVDD）、실간격후도（IVS）、좌심실후벽후도（LVPW）급좌심실질량지수（LVMI）정정상관（r＝0.27～0.35，P＜0.01）。CysC여사혈분수（EF）치부상관（r＝－0.39，P＜0.01），여뇌납태（BNP）수평정정상관（ r＝0.29，P＜0.01）。CysC수평여심공능분급간정정상관（ r＝0.56，P＜0.01）。결론고령고혈압환자혈청CysC수평여좌심실비후급심공능밀절상관，가작위반영좌심실비후정도급심공능분급적중요지표지일。
Objective To study the correlation among the levels of serum Cystatin C ’left ventricular hypertrophy and heart function in elderly hypertensives.Methods According to the LVMI and the heart function grade of NYHA ,110 elderly hypertensives were divided into left ventricular hypertrophy group (LVH Group) and non_hypertrophic group (non_LVH Group) ,the relationship between each group’s levels of serum Cystatin C and the cardiac function was studied.Results The levels of serum Cystatin C in the LVH group was significantly raised by contrast with that in the NVH group ,there were statistically significant differences ( P<0.01).The Cystatin C concentration of serum had positive correlation with LVDD ,IVS ,LVPW and LVMI ( r=0.27~0.35 , P<0.01 ).Cystatin C had a negativecorrelationwithEFvalue (r= -0.39,P<0.01),andapositivecorrelationwithBNPlevel (r=0.29,P<0.01).The Cystatin C level had a positive correlation with the class of heart function ( r=0.56 , P<0.01 ). Conclusions The levels of serum Cystatin C had close relationship with the left ventricular hypertrophy and heart function in elderly hypertensives ,and it may used as an important indicator of predicting the levels of left ventricular hypertrophy and heart function.
