中华眼科医学杂志（电子版）
中華眼科醫學雜誌（電子版）
중화안과의학잡지（전자판）
CHINESE JOURNAL OF OPHTHALMOLOGIC MEDICINE(ELECTRONIC EDITION)
2015年
1期
44-46
,共3页
高度近视眼%发病机制%巩膜%细胞外基质
高度近視眼%髮病機製%鞏膜%細胞外基質
고도근시안%발병궤제%공막%세포외기질
High myopia%Sclera%Pathogenesis%Extracellular matrix
目前已经有研究证实，视网膜能够独立识别眼球的屈光状态并做出相应的反应，是眼球生长控制系统的感觉运动器。视觉传导的信号分子从视网膜传递到巩膜，最后引起巩膜的重塑。由于巩膜决定眼球的形状和大小，因此巩膜的变化是近视眼研究的焦点。目前已经有大量研究报道，眼球伸长的过程伴随着巩膜的广泛重塑。局部视网膜信号转化为调控巩膜重塑的信号后，可诱导细胞外基质的异常表达，并引起巩膜胶原纤维的改变，最终引起巩膜重塑。本文笔者就巩膜细胞外基质在高度近视眼发病机制中的作用进行综述。
目前已經有研究證實，視網膜能夠獨立識彆眼毬的屈光狀態併做齣相應的反應，是眼毬生長控製繫統的感覺運動器。視覺傳導的信號分子從視網膜傳遞到鞏膜，最後引起鞏膜的重塑。由于鞏膜決定眼毬的形狀和大小，因此鞏膜的變化是近視眼研究的焦點。目前已經有大量研究報道，眼毬伸長的過程伴隨著鞏膜的廣汎重塑。跼部視網膜信號轉化為調控鞏膜重塑的信號後，可誘導細胞外基質的異常錶達，併引起鞏膜膠原纖維的改變，最終引起鞏膜重塑。本文筆者就鞏膜細胞外基質在高度近視眼髮病機製中的作用進行綜述。
목전이경유연구증실，시망막능구독립식별안구적굴광상태병주출상응적반응，시안구생장공제계통적감각운동기。시각전도적신호분자종시망막전체도공막，최후인기공막적중소。유우공막결정안구적형상화대소，인차공막적변화시근시안연구적초점。목전이경유대량연구보도，안구신장적과정반수착공막적엄범중소。국부시망막신호전화위조공공막중소적신호후，가유도세포외기질적이상표체，병인기공막효원섬유적개변，최종인기공막중소。본문필자취공막세포외기질재고도근시안발병궤제중적작용진행종술。
Currently, there is experimental evidence showing that retina encompasses an entire sensorimotor apparatus that controls eyeball growth by independently identifying the refractive state of the eye and making appropriate responses accordingly.It is known that visual signals are transduced from the retina to the sclera,eventually reshaping the sclera.Given that the sclera determines the shape and size of the eyeball, the sclera has been the focus in myopia research.To date,numerous studies have demonstrated that:eyeball elongation is accompanied by the sclera remodeling and he local retinal signals, after transforming into remodeling-regulatory signals, may lead to aberrant expression of extracellular matrix components in the scleral cells and subsequent changes in the scleral collagen fibers.This paper aims to review the recent progress in the research on the role for scleral extracellular matrix in the pathogenesis of high myopia.
