CAJ | 학술논문

目的：探讨多排螺旋 CT 灌注成像对肝炎、肝纤维化和早期肝硬化诊断的临床意义。方法收集2012年9月至2013年9月来我院就诊的35例乙型肝炎患者作为观察组A，32例轻度肝纤维化患者作为观察组B，38例重度肝纤维化患者作为观察组C，41例早期肝硬化患者作为观察组D，健康研究对象35例作为对照组，五组均进行CT灌注扫描。结果观察组A及观察组B的HAP与对照组比较明显较低，观察组C及观察组D的HAP与观察组A、观察组B及对照组比较明显较高（ P＜0．05）；对照组、观察组A、观察组B、观察组C、观察组D的PVP、TLP依次降低，HPI及TTP依次升高（ P＜0．05）。 PVP、TLP显著负相关于肝纤维化严重程度，而HAP、HPI及TTP显著正相关于肝纤维化严重程度（P＜0．05）。PVP的Logistic多因素回归分析标准化回归系数为－8．354。结论肝炎、不同程度肝纤维化及肝硬化各阶段肝脏血流灌注变化特点可以通过多排螺旋CT灌注成像参数反映，各参数中敏感性最强的为PVP。
목적：탐토다배라선 CT 관주성상대간염、간섬유화화조기간경화진단적림상의의。방법수집2012년9월지2013년9월래아원취진적35례을형간염환자작위관찰조A，32례경도간섬유화환자작위관찰조B，38례중도간섬유화환자작위관찰조C，41례조기간경화환자작위관찰조D，건강연구대상35례작위대조조，오조균진행CT관주소묘。결과관찰조A급관찰조B적HAP여대조조비교명현교저，관찰조C급관찰조D적HAP여관찰조A、관찰조B급대조조비교명현교고（ P＜0．05）；대조조、관찰조A、관찰조B、관찰조C、관찰조D적PVP、TLP의차강저，HPI급TTP의차승고（ P＜0．05）。 PVP、TLP현저부상관우간섬유화엄중정도，이HAP、HPI급TTP현저정상관우간섬유화엄중정도（P＜0．05）。PVP적Logistic다인소회귀분석표준화회귀계수위－8．354。결론간염、불동정도간섬유화급간경화각계단간장혈류관주변화특점가이통과다배라선CT관주성상삼수반영，각삼수중민감성최강적위PVP。
Objective We were to investigate the clinical significance of multi-slice spiral CT perfusion imaging in diagnosing hepatitis, liver fibrosis and early cirrhosis.Methods During September 2012 and September 2013, 35 cases of hepatitis B patients in our hospital were selected as observation group A, 32 patients with mild hepatic fibrosis as the observation group B, 38 patients with severe liver fibrosis patients as observation group C, 41 patients with early cirrhosis as the observation group D, 35 cases of healthy subjects as the control group, all the objects in the five groups were performed CT perfusion scan.Results HAP of Observation group A and observation group B were significantly lower than that of control group, HAPofthe observation group C and observation group D were significantly higher than that of observation group A, group B and the control group (P<0.05).PVP and TLP descending order in the control group, observation group A, the observation group B, the observation group C, observation group D.On the contrast, HPI and TTP increased in turn (P<0.05).PVP, TLP negatively correlatedwiththe severity of liver fibrosis.HAP, HPI and TTP positively correlated with the severity of liver fibrosis (P<0.05).Standardized regression coefficient of PVP Logistic regression analysis was-8.354.Conclusions Hepatitis, hepatic blood flow to varying degrees various stages of liver fibrosis and cirrhosis of the liver perfusion changes can be characterized by multi-slice spiral CT perfusion imaging parameters, the strongest and sensitivity parameters was PVP.