局解手术学杂志
跼解手術學雜誌
국해수술학잡지
JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY
2015年
2期
192-194
,共3页
唐博%谭群友%王如文%周景海%邓波%康珀铭%戴富强%蒋彬%钱凯%陶绍霖
唐博%譚群友%王如文%週景海%鄧波%康珀銘%戴富彊%蔣彬%錢凱%陶紹霖
당박%담군우%왕여문%주경해%산파%강박명%대부강%장빈%전개%도소림
恶性胸腔积液%重组人p53腺病毒%肺癌%生活质量
噁性胸腔積液%重組人p53腺病毒%肺癌%生活質量
악성흉강적액%중조인p53선병독%폐암%생활질량
malignant pleural effusion%rAd-P53 gene%lung cancer%quality of life
目的：探讨胸腔内注射重组人腺病毒( rAd-p53)对肺癌恶性胸腔积液的疗效。方法36例伴有恶性胸腔积液的肺癌患者随机分为2组,采用胸腔内注射rAd-p53联合静脉输注奈达铂治疗为观察组( n=20),采用单纯静脉输注奈达铂治疗为对照组(n=16)。比较2种方案的胸腔积液的控制有效率,并检测最大自主通气量(MVV)和Kamofsky评分(KPS),比较2组治疗前后的肺功能和生活质量的改变。结果观察组胸腔积液有效控制率85%(17/20)高于对照组50%(8/16),差异显著(P<0.05)。观察组治疗后KPS≥80分者由25%(5/20)上升至55%(11/20),P<0.05；对照组治疗前后差异不明显,P>0.05。结论胸腔内注射rAd-p53联合化疗更能有效控制肺癌恶性胸腔积液的产生,并提高患者生活质量。
目的：探討胸腔內註射重組人腺病毒( rAd-p53)對肺癌噁性胸腔積液的療效。方法36例伴有噁性胸腔積液的肺癌患者隨機分為2組,採用胸腔內註射rAd-p53聯閤靜脈輸註奈達鉑治療為觀察組( n=20),採用單純靜脈輸註奈達鉑治療為對照組(n=16)。比較2種方案的胸腔積液的控製有效率,併檢測最大自主通氣量(MVV)和Kamofsky評分(KPS),比較2組治療前後的肺功能和生活質量的改變。結果觀察組胸腔積液有效控製率85%(17/20)高于對照組50%(8/16),差異顯著(P<0.05)。觀察組治療後KPS≥80分者由25%(5/20)上升至55%(11/20),P<0.05；對照組治療前後差異不明顯,P>0.05。結論胸腔內註射rAd-p53聯閤化療更能有效控製肺癌噁性胸腔積液的產生,併提高患者生活質量。
목적：탐토흉강내주사중조인선병독( rAd-p53)대폐암악성흉강적액적료효。방법36례반유악성흉강적액적폐암환자수궤분위2조,채용흉강내주사rAd-p53연합정맥수주내체박치료위관찰조( n=20),채용단순정맥수주내체박치료위대조조(n=16)。비교2충방안적흉강적액적공제유효솔,병검측최대자주통기량(MVV)화Kamofsky평분(KPS),비교2조치료전후적폐공능화생활질량적개변。결과관찰조흉강적액유효공제솔85%(17/20)고우대조조50%(8/16),차이현저(P<0.05)。관찰조치료후KPS≥80분자유25%(5/20)상승지55%(11/20),P<0.05；대조조치료전후차이불명현,P>0.05。결론흉강내주사rAd-p53연합화료경능유효공제폐암악성흉강적액적산생,병제고환자생활질량。
Objective To assess the therapeutic efficacy of a recombined adenovirus expressing p53 (rAd-p53) via intrapleural injec-tion in the treatment of lung cancer with malignant pleural effusion. Methods Thirty-six cases with lung cancer and malignant pleural effu-sion were randomly divided into two groups,which were given intravenous injection of Nedaplatin with (observation group,n=20) or without (control group,n=16) intrapleural injection of rAd-p53,respectively. Between the two groups,the efficacy in treatment of pleural effusion, the amelioration of maximal ventilatory volume ( MVV) ,Kamofsky scoring ( KPS) and quality of life were compared. Results The efficacy in treatment of pleural effusion in observation group are significantly higher than that in control group(17/20 vs. 50%,P<0. 05). The cases with KPS≥80 in observation group were significantly increased following treatment (5/20 vs. 11/20,P <0. 05). However,there was no difference with the cases in control group. Conclusion Intrapleural injection of recombinant adenovirus expressing p53 (rAd-p53) is effec-tive to reduce the occurrence of malignant pleural effusion and increase the quality of life remarkably.
