CAJ | 학술논문

目的：探讨宫颈癌动态增强磁共振成像( DCE-MRI)半定量参数与血氧水平依赖磁共振成像( BOLD-MRI)基线R2?的相关性,为肿瘤乏氧检测技术的进一步发展奠定基础。方法24例宫颈癌患者在治疗前行DCE-MRI及BOLD-MRI检查,应用专用后处理软件获得DCE-MRI半定量参数( SI-I、MER、Tmax、IAUC)及BOLD-MRI参数(基线R2*),分析DCE-MRI半定量参数与BOLD-MRI基线R2?的相关性。结果基线R2?与Tmax呈正相关(r=0.423,P=0.014),基线R2?与SI-I、MER及IAUC无显著相关性(P>0.05)。结论 DCE-MRI半定量参数与BOLD-MRI基线R2?以不同原理反映肿瘤的氧合程度,联合应用上述参数有望提高肿瘤乏氧检测的性能。
목적：탐토궁경암동태증강자공진성상( DCE-MRI)반정량삼수여혈양수평의뢰자공진성상( BOLD-MRI)기선R2?적상관성,위종류핍양검측기술적진일보발전전정기출。방법24례궁경암환자재치료전행DCE-MRI급BOLD-MRI검사,응용전용후처리연건획득DCE-MRI반정량삼수( SI-I、MER、Tmax、IAUC)급BOLD-MRI삼수(기선R2*),분석DCE-MRI반정량삼수여BOLD-MRI기선R2?적상관성。결과기선R2?여Tmax정정상관(r=0.423,P=0.014),기선R2?여SI-I、MER급IAUC무현저상관성(P>0.05)。결론 DCE-MRI반정량삼수여BOLD-MRI기선R2?이불동원리반영종류적양합정도,연합응용상술삼수유망제고종류핍양검측적성능。
Objective To investigate the relationships between baseline R2? of blood oxygenation level-dependent magnetic resonance imaging(BOLD-MRI) and Semi-quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) in cervical cancer,to lay a foundation for the further development of assessing tumor hypoxia techniques. Methods Twenty-four patients with cervical cancer were subjected to DCE-MRI and BOLD-MRI before treatment,Semi-quantitative parameters(SI-I、MER、Tmax、IAUC) of DCE-MRI and the baseline R2?of BOLD-MRI produced by special post-processing softwares,the relationships between baseline R2?of BOLD-MRI and Semi-quantitative parameters of DCE-MRI were analyzed. Results Significant positive correlations were observed between baseline R2?and Tmax(r=0.423,P=0.014),there were no correlation between baseline R2? and SI-I、MER or IAUC(P>0.05). Conclusion Semi-quantitative parameters of DCE-MRI and baseline R2? of BOLD-MRI respectively reflected the oxygenation of tumor in different principle. The combined use of the above parameters is expected to improve the performance for defining tumor hypoxia.