CAJ | 학술논문

目的：探讨正性脾自体移植对DEN诱发大鼠肝癌的治疗作用。方法40只健康大鼠平均随机分为A、B 2组，全部行脾切除，切除的脾冻存于液氮中；以DEN液喂食切除脾的大鼠以诱导肝癌；12周后诱癌成功的A组大鼠行自体脾移植，诱癌成功的B组假手术作为对照。结果 A组大鼠术后生存期显著高于B组大鼠，但A组大鼠死亡时移植脾组织尚未恢复到正常形态结构。结论正性脾自体移植对DEN诱发的大鼠肝癌具有治疗作用。
목적：탐토정성비자체이식대DEN유발대서간암적치료작용。방법40지건강대서평균수궤분위A、B 2조，전부행비절제，절제적비동존우액담중；이DEN액위식절제비적대서이유도간암；12주후유암성공적A조대서행자체비이식，유암성공적B조가수술작위대조。결과 A조대서술후생존기현저고우B조대서，단A조대서사망시이식비조직상미회복도정상형태결구。결론정성비자체이식대DEN유발적대서간암구유치료작용。
Objective To investigate the therapeutic effect of autologous transplantation of spleen on rat liver cancer induced by DEN. Methods Forty rats were randomly divided into A and B group on average. Total spleens of 40 rats were resected, which preserved in liquid nitrogen. All splenectomy rats were feeded with DEN to induce hepatocellular carcinoma. After 12 weeks ,all rats which had were successfully induced liver cancer were transplanted by autologous spleen in group A. Group B were sham operation as control. Results Survival period was significantly higher in group A than that in group B. But transplanted splenic tissue had not recovered to normal morphological structure until these rats died. Conclusion Autologous transplantation of spleen has therapeutic effect for liver cancer induced by DEN.