CAJ | 학술논문

目的：探讨食管颗粒细胞瘤的病理形态、诊断、鉴别诊断及预后。方法回顾性分析我院2008年至2014年7例经病理诊断为食管颗粒细胞瘤患者的临床资料。采用常规HE染色及免疫组化法分析7例食管颗粒细胞瘤的病理特征及与临床资料间的关系。结果7例患者肿瘤均位于食管黏膜下层,呈灰白至灰黄色,结节状,无包膜；直径0.4~1.0 cm。镜下：肿瘤细胞呈圆形、多边形或梭形,胞质丰富呈嗜酸性颗粒状,细胞核小,核仁不明显,大多位于中央,未见核分裂像。免疫组化：肿瘤细胞S-100、CD68和NSE阳性,SMA、desmin、CK、CD34、CD117、DOG 1、HMB45阴性,Ki-67低表达。组织化学：PAS阳性。7例全部为良性肿瘤,随访8个月至6年,无复发病例。结论食管颗粒细胞瘤是比较少见的软组织肿瘤,多位于食管中下段,绝大多数为良性肿瘤,预后较好,确诊依赖于病理诊断。
목적：탐토식관과립세포류적병리형태、진단、감별진단급예후。방법회고성분석아원2008년지2014년7례경병리진단위식관과립세포류환자적림상자료。채용상규HE염색급면역조화법분석7례식관과립세포류적병리특정급여림상자료간적관계。결과7례환자종류균위우식관점막하층,정회백지회황색,결절상,무포막；직경0.4~1.0 cm。경하：종류세포정원형、다변형혹사형,포질봉부정기산성과립상,세포핵소,핵인불명현,대다위우중앙,미견핵분렬상。면역조화：종류세포S-100、CD68화NSE양성,SMA、desmin、CK、CD34、CD117、DOG 1、HMB45음성,Ki-67저표체。조직화학：PAS양성。7례전부위량성종류,수방8개월지6년,무복발병례。결론식관과립세포류시비교소견적연조직종류,다위우식관중하단,절대다수위량성종류,예후교호,학진의뢰우병리진단。
Objective To investigate the pathological feathers,diagnosis,differential diagnosis and prognosis of esophageal granular cell tumor. Methods The data of seven patients of esophageal granular cell tumor diagnosed from 2008 to 2014 in our hospital were analyzed. Seven cases of esophageal granular cell tumor were studied by hematoxylin-eosin and EliVision immunohistochemical staining,the clinical and pathological feathers were analyzed with review of the literatures. Results The pathological feathers of seven cases were very typical. The tumors located in the submucosa,and showed gray to grayish yellow,nodular,with no capsule. The size of these tumors ranged from 0. 4 ~1. 0 cm in diameter. Microscopically,the tumor cells were round,polygonal or spindle with small central nuclei and rich eosinophilic granules cytoplasm,the nucleolus could not be easily seen. Immunohistochemical stain showed that the tumor cells were positive for S-100,CD68 and NSE,but negative for SMA,Desmin,CK,CD34,CD117,DOG1,HMB45. The proportion of Ki-67 positive cells was very low. Histochemical stain showed that the tumor cells were positive for PAS. All 7 cases were benign,and the follow-up time was from 8 months to 6 years without recurrence in patients. Conclusion Granular cell tumor of esophagus is very rare in soft tissue tumors,most of which are benign and located in the middle and lower segment of esophagus. The tumor has a better prognosis. The definite diagnosis should depend on the pathological di-agnosis.