CAJ | 학술논문

目的回顾性研究卵巢功能早衰女性骨质疏松情况，完善流行病学的资料。方法164例绝经年龄小于40岁，实际年龄小于70岁的女性分为两组，其中A组为36岁以前绝经有50例，B组为36~39岁绝经有114例。追问女性停经原因，血液中的生化指标，如骨钙素N端中分子片段（N-MID）、I型胶原C端肽降解产物（CTX-I）、25-羟基维生素D（25-OH-VD）、甲状旁腺素（PTH）、骨钙素（BGP）、降钙素（CT）等骨转换标志物。结果 A、B两组25-羟基维生素D的均值均低于正常参考值。做2个独立样本间的检验，N-MID指标B组均值低于C组（=-3.47,<0.01），25-OH-VD指标A组均值低于C组（=-3.02,<0.01），25-OH-VD指标B组均值低于C组（=-2.89,<0.01）。其余各组间没有统计学差异。结论关注卵巢功能早衰女性骨密度状况十分重要，女性在绝经以后骨质疏松的概率会大增，成为易发骨质疏松症的人群，就算是年轻女性绝经后也有必要定期进行骨质疏松的检测，了解自己的骨质情况，预防骨质疏松症。
목적회고성연구란소공능조쇠녀성골질소송정황，완선류행병학적자료。방법164례절경년령소우40세，실제년령소우70세적녀성분위량조，기중A조위36세이전절경유50례，B조위36~39세절경유114례。추문녀성정경원인，혈액중적생화지표，여골개소N단중분자편단（N-MID）、I형효원C단태강해산물（CTX-I）、25-간기유생소D（25-OH-VD）、갑상방선소（PTH）、골개소（BGP）、강개소（CT）등골전환표지물。결과 A、B량조25-간기유생소D적균치균저우정상삼고치。주2개독립양본간적검험，N-MID지표B조균치저우C조（=-3.47,<0.01），25-OH-VD지표A조균치저우C조（=-3.02,<0.01），25-OH-VD지표B조균치저우C조（=-2.89,<0.01）。기여각조간몰유통계학차이。결론관주란소공능조쇠녀성골밀도상황십분중요，녀성재절경이후골질소송적개솔회대증，성위역발골질소송증적인군，취산시년경녀성절경후야유필요정기진행골질소송적검측，료해자기적골질정황，예방골질소송증。
Objective To do a retrospective study on the present osteoporosis situations of women with premature ovarian failure, improve epidemiological data.Methods 164 cases of postmenopausal women aged less than 40 years, the actual women less than 70 years of age were divided into 2 groups, A group is 36 years old before menopause in 50 cases, B group was 36~39 years of menopause in 114 cases. Ask the reason of female menopause, blood biochemical indexes, such as molecule osteocalcin in N terminal fragment (N-MID), type I col agen C end peptide degradation products (CTX-I), 25-hydroxy vitamin D (25-OH-VD), parathyroid hormone (PTH), osteocalcin (BGP), calcitonin (CT) and other markers of bone turnover. Results The A, B value of two hydroxy vitamin D in 25-group were lower than the normal reference value. Do 2 independent samples t test, N-MID index in B group was lower than that of C group (mean t=-3.47, <0.01), 25-OH-VD index in A group was lower than that of C group (mean t=-3.02, <0.01), 25-OH-VD index of B group mean lower than group C (t=-2.89, <0.01). In other group no significant dif erences. Conclusion To pay at ention to premature ovarian failure in women bone density in women is very important, the probability of osteoporosis after menopause Osteoporosis wil increase, be prone to osteoporosis in the crowd, even if is the detection of young postmenopausal women wil also be necessary to periodical y osteoporosis bone situation, understand their own, preventing osteoporosis.