CAJ | 학술논문

目的：探讨质子泵抑制剂引发骨质疏松的病变机制和治疗措施。方法60例采取质子泵抑制剂治疗的消化系统疾病患者作为研究对象，根据患者的具体情况选择合适的药物，主要有钙剂和维生素D制剂。骨密度T值≤2．5者加用抗骨质疏松药物。结果经过治疗，患者髋关节和腰椎骨密度T值均有显著性上升（均P＜0．01）。结论对于长期服用质子泵抑制剂的患者来说，有必要定期检测骨密度，同时给予预防性治疗，以降低骨折风险。
목적：탐토질자빙억제제인발골질소송적병변궤제화치료조시。방법60례채취질자빙억제제치료적소화계통질병환자작위연구대상，근거환자적구체정황선택합괄적약물，주요유개제화유생소D제제。골밀도T치≤2．5자가용항골질소송약물。결과경과치료，환자관관절화요추골밀도T치균유현저성상승（균P＜0．01）。결론대우장기복용질자빙억제제적환자래설，유필요정기검측골밀도，동시급여예방성치료，이강저골절풍험。
Objective To study the pathological changes mechanism of osteoporosis caused by proton pump inhibitors and treatment measures.Methods 60 cases treated with proton pump inhibitors in patients with diseases of the digestive system as the research object, according to the specific condition of patients to choose the appropriate drugs, mainly with calcium and vitamin D preparation.Bone mineral density T values add anti osteoporosis drugs 2.5 or less.Results After treatment, patients with hip and T value (density were significantly increased (P<0.01).Conclusions For patients with long-term use of proton pump inhibitors, periodic testing bone mineral density;it is necessary to give preventive treatment at the same time in order to reduce the risk of fractures.