CAJ | 학술논문

目的：分析浸润性乳腺癌不同分子亚型中p53与表皮生长因子受体( EGFR)的表达情况及其相关性。方法回顾性分析山东省肿瘤医院2012年1月至2013年8月264例可手术乳腺癌患者的临床及病理资料,分析分子亚型与临床病理特征的相关性及不同分子亚型中p53与EGFR表达的相关性。结果乳腺癌分子亚型与发病年龄、初潮年龄无统计学差异(均P>0.05)。分子亚型与是否绝经、肿瘤直径、淋巴结转移、病理分期、细胞角蛋白5/6( CK5/6)、p53及EGFR表达状况具有统计学差异(均P<0.05)。 Luminal型乳腺癌患者T1期所占比例多于non-Luminal型乳腺癌患者(P<0.05)。 p53与EGFR总体表达呈正相关(r=0.226,P<0.05),进一步分层分析显示各分子亚型中只有三阴性乳腺癌(TNBC)中p53与EGFR表达呈正相关(r=0.319,P<0.05),其他亚型中p53与EGFR表达无相关性(均P>0.05)。结论 p53与EGFR在TNBC中表达呈正相关,探讨二者的表达有助于进一步了解TNBC的分子生物学特征,并为TNBC的治疗提供新的思路。
목적：분석침윤성유선암불동분자아형중p53여표피생장인자수체( EGFR)적표체정황급기상관성。방법회고성분석산동성종류의원2012년1월지2013년8월264례가수술유선암환자적림상급병리자료,분석분자아형여림상병리특정적상관성급불동분자아형중p53여EGFR표체적상관성。결과유선암분자아형여발병년령、초조년령무통계학차이(균P>0.05)。분자아형여시부절경、종류직경、림파결전이、병리분기、세포각단백5/6( CK5/6)、p53급EGFR표체상황구유통계학차이(균P<0.05)。 Luminal형유선암환자T1기소점비례다우non-Luminal형유선암환자(P<0.05)。 p53여EGFR총체표체정정상관(r=0.226,P<0.05),진일보분층분석현시각분자아형중지유삼음성유선암(TNBC)중p53여EGFR표체정정상관(r=0.319,P<0.05),기타아형중p53여EGFR표체무상관성(균P>0.05)。결론 p53여EGFR재TNBC중표체정정상관,탐토이자적표체유조우진일보료해TNBC적분자생물학특정,병위TNBC적치료제공신적사로。
Objective To investigate the correlation between p53 and EGFR overexpression in distinct mo-lecular subtypes of invasive breast cancer. Methods The clinicopathology data of 264 operable breast cancer patients from January 2012 to August 2013 were retrospectively analyzed, and the correlation of p53 and epider-mal growth factor receptor ( EGFR) expression in distinct molecular subtypes was investigated. Results No sta-tistically significant differences were found among distinct molecular subtypes regarding age at diagnosis and age at menarche by using chi-square test(all P>0. 05). Statistically significant differences were found among dis-tinct molecular subtypes regarding menopause status, tumor size, lymph node status, pathological stage , Cytok-eratin 5/6 (CK5/6), p53 and EGFR (all P<0. 05). There were more patients with T1 stage in Luminal sub-type than that of in non-luminal subtype (P<0. 05). p53 expression had a positive correlation with EGFR ex-pression in invasive breast cancer (r=0. 226,P<0. 05). There was a significant positive correction between p53 and EGFR in triple-negative breast cancer (TNBC) by stratification analysis (r=0. 319,P<0. 05), not in other subtypes(all P>0. 05). Conclusions There was a positive correlation between p53 and EGFR in TNBC. P53 and EGFR in TNBC may help us to comprehensively recognize the molecular biological characteristics of TNBC,and may offer us a new idea to TNBC treatment.