CAJ | 학술논문

缺氧微环境是实体肿瘤的典型特征，被认为是导致肿瘤进展及预后差的独立因素；作为肿瘤干细胞（cancer stem cells，CSCs）壁龛的关键组成部分，缺氧微环境对肿瘤干细胞在肿瘤中的演进以及抗凋亡能力起着重要的作用。缺氧诱导因子（hypoxia-inducible factors，HIFs）是肿瘤适应缺氧微环境的中心调节因子，能够诱导肿瘤干细胞生物学行为的改变如抗凋亡、增强耐药基因表达、促进肿瘤侵袭转移等，从而加速肿瘤恶性转变；同时HIFs也是维持肿瘤干细胞其干细胞特性的主要影响因素。本文对HIFs在维持肿瘤干细胞生物学特性的研究进展进行综述。
결양미배경시실체종류적전형특정，피인위시도치종류진전급예후차적독립인소；작위종류간세포（cancer stem cells，CSCs）벽감적관건조성부분，결양미배경대종류간세포재종류중적연진이급항조망능력기착중요적작용。결양유도인자（hypoxia-inducible factors，HIFs）시종류괄응결양미배경적중심조절인자，능구유도종류간세포생물학행위적개변여항조망、증강내약기인표체、촉진종류침습전이등，종이가속종류악성전변；동시HIFs야시유지종류간세포기간세포특성적주요영향인소。본문대HIFs재유지종류간세포생물학특성적연구진전진행종술。
Hypoxic microenvironment is a typical characteristic of solid tumors and is considered an independent risk factor in tu-mor progression and poor prognosis. Hypoxic microenvironment is a critical part of cancer stem cell (CSC) niche and plays an impor-tant role in the evolution of cancer stem cells in tumors and in apoptosis resistance. As a key factor in the tumor's adaption to hypoxic microenvironment, hypoxia inducible factors (HIFs) can induce biological behavioral changes in CSCs that can accelerate tumor malig-nant transformation. Such behavioral changes include anti-apoptosis, enhancement of drug-resistance gene expression, and tumor inva-sion and metastasis. HIFs are also among the main factors affecting the capacity of CSCs to maintain their biological characteristics. In this review, the authors focus on recent advances in our understanding of the role that HIFs play in maintaining the biological character-istics of CSCs.