CAJ | 학술논문

目的：探讨术前大分割短程放疗与常规分割长程放疗对直肠癌根治术患者的临床疗效和不良反应。方法将2010年9月至2013年9月收治的cT2-3 N0-2 M0直肠癌患者随机分成短程组和长程组。短程组给予大分割短程放疗,7~8周后行直肠癌根治术；长程组给予常规分割长程放疗,4~6周后行直肠癌根治术。比较两组患者完全病理学应答率、围手术期不良反应。结果短程组和长程组术后完全病理学应答率为15.1%与15.6%,P>0.05。两组患者切口感染、腹腔内感染、出血、吻合口瘘、切口不愈合发生率、术后1年复发率和死亡率相近。结论两组患者具有相似的完全病理学应答率、围手术期不良反应发生率、术后1年复发率和死亡率。
목적：탐토술전대분할단정방료여상규분할장정방료대직장암근치술환자적림상료효화불량반응。방법장2010년9월지2013년9월수치적cT2-3 N0-2 M0직장암환자수궤분성단정조화장정조。단정조급여대분할단정방료,7~8주후행직장암근치술；장정조급여상규분할장정방료,4~6주후행직장암근치술。비교량조환자완전병이학응답솔、위수술기불량반응。결과단정조화장정조술후완전병이학응답솔위15.1%여15.6%,P>0.05。량조환자절구감염、복강내감염、출혈、문합구루、절구불유합발생솔、술후1년복발솔화사망솔상근。결론량조환자구유상사적완전병이학응답솔、위수술기불량반응발생솔、술후1년복발솔화사망솔。
Objective To investigate the clinical effect and adverse reaction of preoperative short-course and long-course radiotherapy in radical operation of rectal carcinoma. Methods Some patients staged as cT2-3 N0-2 M0 were randomly arranged into two group,short-course group received radiotherapy and surgery after 7~8 weeks,long-course group received radiotherapy and surgery after 4~6 weeks. Results The rate complete path-ological of response was 15. 1% for patients who received short-course radiotherapy and 15. 6% for patients who had long-course radiotherapy. There were no significant differences between two groups and there were similar wound infection, intra-abdominal infection, haemorrhage, anastomotic leak, wound dehiscence, mortality and recurrence rate 1 year after surgery in two groups. Conclusions The rate complete pathological of response, adverse reaction, mortality and recurrence 1 year after surgery in two groups were similar.