中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
10期
50-52,53
,共4页
瑞舒伐他汀%氟伐他汀%不稳定型心绞痛%血脂
瑞舒伐他汀%氟伐他汀%不穩定型心絞痛%血脂
서서벌타정%불벌타정%불은정형심교통%혈지
Rosuvastatin%Fluvastatin%Unstable angina%Lipids
目的：探讨瑞舒伐他汀与氟伐他汀对不稳定型心绞痛（unstable angina，UA）的调脂作用的临床疗效。方法：将98例UA患者随机分为观察组和对照组，每组各49例患者。在常规治疗包括硝酸酯类、抗血小板药物、钙离子拮抗剂和抗凝血药物基础上，对照组加服氟伐他汀20 mg，口服1次/晚；观察组加服瑞舒伐他汀10 mg，口服1次/晚，两组观察时间均为8周，观察两组的临床疗效和治疗前后血脂及C-反应蛋白（C-response protein，CRP）浓度的变化情况。结果：两组患者的临床症状均改善，观察组与对照组比较，有效率分别为93.88%和79.59%，两组比较差异有统计学意义（P<0.05）；血总胆固醇、甘油三酯、低密度脂蛋白及CRP浓度明显降低（P<0.05）；血高密度脂蛋白明显升高（P<0.05）。结论：瑞舒伐他汀和氟伐他汀均可以改善不稳定型心绞痛患者的临床症状，调脂作用效果明显，而瑞舒伐他汀的效果更好于氟伐他汀。
目的：探討瑞舒伐他汀與氟伐他汀對不穩定型心絞痛（unstable angina，UA）的調脂作用的臨床療效。方法：將98例UA患者隨機分為觀察組和對照組，每組各49例患者。在常規治療包括硝痠酯類、抗血小闆藥物、鈣離子拮抗劑和抗凝血藥物基礎上，對照組加服氟伐他汀20 mg，口服1次/晚；觀察組加服瑞舒伐他汀10 mg，口服1次/晚，兩組觀察時間均為8週，觀察兩組的臨床療效和治療前後血脂及C-反應蛋白（C-response protein，CRP）濃度的變化情況。結果：兩組患者的臨床癥狀均改善，觀察組與對照組比較，有效率分彆為93.88%和79.59%，兩組比較差異有統計學意義（P<0.05）；血總膽固醇、甘油三酯、低密度脂蛋白及CRP濃度明顯降低（P<0.05）；血高密度脂蛋白明顯升高（P<0.05）。結論：瑞舒伐他汀和氟伐他汀均可以改善不穩定型心絞痛患者的臨床癥狀，調脂作用效果明顯，而瑞舒伐他汀的效果更好于氟伐他汀。
목적：탐토서서벌타정여불벌타정대불은정형심교통（unstable angina，UA）적조지작용적림상료효。방법：장98례UA환자수궤분위관찰조화대조조，매조각49례환자。재상규치료포괄초산지류、항혈소판약물、개리자길항제화항응혈약물기출상，대조조가복불벌타정20 mg，구복1차/만；관찰조가복서서벌타정10 mg，구복1차/만，량조관찰시간균위8주，관찰량조적림상료효화치료전후혈지급C-반응단백（C-response protein，CRP）농도적변화정황。결과：량조환자적림상증상균개선，관찰조여대조조비교，유효솔분별위93.88%화79.59%，량조비교차이유통계학의의（P<0.05）；혈총담고순、감유삼지、저밀도지단백급CRP농도명현강저（P<0.05）；혈고밀도지단백명현승고（P<0.05）。결론：서서벌타정화불벌타정균가이개선불은정형심교통환자적림상증상，조지작용효과명현，이서서벌타정적효과경호우불벌타정。
Objective:To investigate the rosuvastatin and fluvastatin clinical efficacy of statin lipid-lowering effects of unstable angina.Method:98 cases were randomly divided into observation group and control group, 49 cases in each group.In the conventional treatment including nitrates, anti-platelet drugs, calcium antagonists and anti-clotting drugs on the basis of that,the control group was took fluvastatin 20 mg, orally once every night;observation group was took rosuvastatin 10 mg, orally once every night,the observation times of two groups were 8 weeks.The clinical efficacy and changes of before and after treatment of lipid and C-reactive protein (C-response protein, CRP) concentrations in both groups were Observed.Result:The clinical improvement in symptoms of both groups,compared with the control group,the response rate was respectively 93.88% and 79.59%(P<0.05);total cholesterol, triglycerides, LDL and CRP levels of observation group were significantly lower,the differences were statistically significant (P<0.05);serum high-density lipoprotein of observation group significantly increased, the difference was statistically significant (P<0.05). Conclusion:Aosuvastatin and fluvastatin can improve clinical symptoms in patients with unstable angina, lipid effects obvious, and rosuvastatin are better than fluvastatin.
