CAJ | 학술논문

目的：探讨阿托伐他汀联合低分子肝素治疗慢性阻塞性肺疾病(COPD)急性加重期的临床效果。方法50例慢性阻塞性肺疾病急性加重期患者，随机分为观察组和对照组，每组25例。对照组采用常规治疗，观察组在常规治疗的基础上给予低分子肝素和阿托伐他汀联合治疗。评定治疗效果。结果观察组治疗后的动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、血氧饱和度及凝血酶原时间和对照组比较，差异有统计学意义(P<0.05)。观察组治疗后的总有效率96.0%高于对照组68.0%，差异有统计学意义(P<0.05)。结论阿托伐他汀联合低分子肝素治疗慢性阻塞性肺疾病急性加重期疗效显著，值得借鉴。
목적：탐토아탁벌타정연합저분자간소치료만성조새성폐질병(COPD)급성가중기적림상효과。방법50례만성조새성폐질병급성가중기환자，수궤분위관찰조화대조조，매조25례。대조조채용상규치료，관찰조재상규치료적기출상급여저분자간소화아탁벌타정연합치료。평정치료효과。결과관찰조치료후적동맥혈이양화탄분압(PaCO2)、동맥혈양분압(PaO2)、혈양포화도급응혈매원시간화대조조비교，차이유통계학의의(P<0.05)。관찰조치료후적총유효솔96.0%고우대조조68.0%，차이유통계학의의(P<0.05)。결론아탁벌타정연합저분자간소치료만성조새성폐질병급성가중기료효현저，치득차감。
Objective To investigate the clinical effect of atorvastatin combined with low molecular heparin in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 50 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into observation group and control group, with 25 cases in each group. The control group received conventional treatment, and the observation group received additional combined treatment by atorvastatin and low molecular. Curative effects were evaluated. Results There were statistically significant differences of arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2), oxyhemoglobin saturation, and prothrombin time between the observation group and control group (P<0.05). The observation group had higher total effective rate after treatment as 96.0% than 68.0% of the control group, and the difference had statistical significance (P<0.05). Conclusion Combination of atorvastatin and low molecular provides remarkable effect in treating acute exacerbation of chronic obstructive pulmonary disease, and this method is worthy of reference.