CAJ | 학술논문

目的探讨双氯芬酸栓加黄体酮在肾绞痛中的临床应用。方法我院自2001年11月~2011年11月应用双氯芬酸栓加黄体酮治疗肾绞痛210例，肾绞痛发作时直肠给药双氯芬酸栓50 mg和肌注黄体酮40 mg，对疼痛缓解欠佳者，每隔6~12 h可重复用药1次，共3~4 d。结果210例中，显效150例，缓解45例，无效15例，复发30例，复发率14.28%，每隔6~12 h重复用药1次均得到缓解。结论双氯芬酸栓是一种新型强效消炎镇痛药，通过抑制前列腺素合成酶的作用，减少体内前列腺素的合成与释放，从而疼痛得以缓解，其作用较消炎痛强2倍，黄体酮为一种孕激素，主要作用于β受体，使输尿管平滑肌松弛，从而起到解痉止痛，且还有溶质性利尿。
목적탐토쌍록분산전가황체동재신교통중적림상응용。방법아원자2001년11월~2011년11월응용쌍록분산전가황체동치료신교통210례，신교통발작시직장급약쌍록분산전50 mg화기주황체동40 mg，대동통완해흠가자，매격6~12 h가중복용약1차，공3~4 d。결과210례중，현효150례，완해45례，무효15례，복발30례，복발솔14.28%，매격6~12 h중복용약1차균득도완해。결론쌍록분산전시일충신형강효소염진통약，통과억제전렬선소합성매적작용，감소체내전렬선소적합성여석방，종이동통득이완해，기작용교소염통강2배，황체동위일충잉격소，주요작용우β수체，사수뇨관평활기송이，종이기도해경지통，차환유용질성이뇨。
Objective To study diclofenac suppository plus progestin in clinical application of renal colic. Methods Our hospital since November 2001 to November 2011 application of diclofenac suppository plus progestin treatment of 210 cases of renal colic, renal colic onset rectal drug diclofenac suppository 50 mg and 40 mg muscle injection of progesterone, on pain relief and functional every 6~12 h can repeat use drug 1 times, a total of 3~4 d. Results 210 cases, 150 cases had marked ef ect, al eviate the 45 cases, 15 cases, 30 cases of recur ence, the recur ence rate of 14.28%, every 6 ~ 12 h repeat use drug 1 times. Conclusion Diclofenac suppository is a new kind of potent anti-inflammatory analgesic, by inhibiting the ef ect of prostaglandin synthetase, reduce the synthesis and release of prostaglandins in the body, thus the pain eased, the role of 2 times more than indomethacin, progesterone is a kind of progesterone, a major role in beta receptors, make the ureteral smooth muscle relaxation, thereby spasmolysis acetanilide, and diuresis and solute.