CAJ | 학술논문

目的探讨辛伐他汀对临床前期下肢动脉硬化闭塞症病程进展的干预作用。方法对2011年1月—2012年1月在蚌埠医学院第一附属医院体检中心体检的151位临床前期下肢动脉硬化闭塞症的老年患者进行前瞻性临床研究，依自愿原则分为两组：对照组(64例)予一般性生活指导(清淡饮食+进行体育锻炼)，观察组(87例)予一般性生活指导+口服辛伐他汀(10 mg/d)。分别于干预前及干预后9、18个月后对两组患者的颈动脉内膜中膜厚度( CIMT)、踝肱指数( ABI)、臂踝脉搏波传导速度( baPWV)进行观测比较。结果进行干预前、干预后9个月及18个月两组的CIMT未见明显变化，组间比较差异均无统计学意义(P值均>0.05)。进行干预前、干预后9个月两组的ABI对比差异无统计学意义(P值均>0.05)；干预后18个月，观察组ABI高于对照组[(0.96依0.18) vs (0.90依0.18)]，差异有统计学意义(P<0.05)。进行干预前两组的baPWV对比差异无统计学意义(P>0.05)，干预后9、18个月，观察组baPWV低于对照组[(1408.0依172.5) cm/s vs (1517.7依171.7)cm/s]，[(1381.1依176.1)cm/s vs (1501.7依185.3)cm/s]，差异均有统计学意义(P值均<0.05)。结论辛伐他汀有提高ABI及减小baPWV的作用，对临床前期下肢动脉硬化闭塞症患者的病情进展有缓解作用。
목적탐토신벌타정대림상전기하지동맥경화폐새증병정진전적간예작용。방법대2011년1월—2012년1월재방부의학원제일부속의원체검중심체검적151위림상전기하지동맥경화폐새증적노년환자진행전첨성림상연구，의자원원칙분위량조：대조조(64례)여일반성생활지도(청담음식+진행체육단련)，관찰조(87례)여일반성생활지도+구복신벌타정(10 mg/d)。분별우간예전급간예후9、18개월후대량조환자적경동맥내막중막후도( CIMT)、과굉지수( ABI)、비과맥박파전도속도( baPWV)진행관측비교。결과진행간예전、간예후9개월급18개월량조적CIMT미견명현변화，조간비교차이균무통계학의의(P치균>0.05)。진행간예전、간예후9개월량조적ABI대비차이무통계학의의(P치균>0.05)；간예후18개월，관찰조ABI고우대조조[(0.96의0.18) vs (0.90의0.18)]，차이유통계학의의(P<0.05)。진행간예전량조적baPWV대비차이무통계학의의(P>0.05)，간예후9、18개월，관찰조baPWV저우대조조[(1408.0의172.5) cm/s vs (1517.7의171.7)cm/s]，[(1381.1의176.1)cm/s vs (1501.7의185.3)cm/s]，차이균유통계학의의(P치균<0.05)。결론신벌타정유제고ABI급감소baPWV적작용，대림상전기하지동맥경화폐새증환자적병정진전유완해작용。
Objective To explore new ideas for arteriosclerosis obliterans by observing the clinical efficacy of simvastatin in preventing preclinical arteriosclerosis obliterans developing. Methods One hundred and fifty-one elderly patients with preclinical arteriosclerosis obliterans were divided into control group(n=64) and experiment group(n=87):everyday life advising (vegetarian diet and moderate exercise and everyday life advising plus taking simvastatin ( 10 mg daily ) . The carotid intima-media thickness ( CIMT) , ankle brachial index ( ABI ) and brachial-ankle pulse wave velocity ( baPWV ) were analyzed comparatively at 9 and 18 months after the treatment. Results There were no statistical differences in the CIMT, ABI and baPWV between the two groups before treatment(all P values >0. 05). There was no statistical difference in the CIMT between the two groups at 9 and 18 months follow-up ( all P values >0. 05). There was no statistical difference in the ABI between the control group and experiment group at 9 months follow-up(P>0. 05), but statistical difference at 18 months follow-up [(0. 94±0. 18) vs (0. 90±0. 18), P < 0. 05]. There were statistical differences in the baPWV between the control group and experiment group at 9 and 18 months follow-up [(1408. 0 ±172. 5) cm/s vs (1517. 7 ±171. 7) cm/s, (1381. 1±176. 1)cm/s vs (1501. 7±185. 3)cm/s, all P values<0. 05]. Conclusions Simvastatin can increase the ABI and decrease the baPWV. It has the efficacy to retard preclinical arteriosclerosis obliterans developing.