中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
10期
98-101,102
,共5页
慢性萎缩性胃炎%胃癌前病变%健脾理气方%Survivin%Fas
慢性萎縮性胃炎%胃癌前病變%健脾理氣方%Survivin%Fas
만성위축성위염%위암전병변%건비리기방%Survivin%Fas
Chronic atrophic gastritis%Precancerous lesions of gastric cancer%Jianpi Liqi Formula%Survivin%Fas
目的：观察健脾理气方对慢性萎缩性胃炎癌前病变的临床疗效及其对凋亡基因Survivin与Fas表达的影响。方法：66例患者按按完全随机化法分为两组，治疗组和对照组各33例。治疗组口服健脾理气方，对照组口服胃复春片，两组均治疗12周。观察两组患者的综合疗效、临床症状、胃镜情况、病理情况、幽门螺旋杆菌（Hp）根除率及Survivin与Fas表达情况。结果：治疗组的综合疗效、临床症状积分、胃镜情况、病理评分和Hp根除率均优于对照组，且可降低Survivin的表达与提高Fas的表达，两组比较差异有统计学意义（P<0.05）。结论：健脾理气方可以明显改善慢性萎缩性胃炎癌前病变患者的临床症状，减轻胃黏膜肠上皮化生和不典型增生程度，其中降低Survivin的表达与提高的Fas表达可能为其机制之一。
目的：觀察健脾理氣方對慢性萎縮性胃炎癌前病變的臨床療效及其對凋亡基因Survivin與Fas錶達的影響。方法：66例患者按按完全隨機化法分為兩組，治療組和對照組各33例。治療組口服健脾理氣方，對照組口服胃複春片，兩組均治療12週。觀察兩組患者的綜閤療效、臨床癥狀、胃鏡情況、病理情況、幽門螺鏇桿菌（Hp）根除率及Survivin與Fas錶達情況。結果：治療組的綜閤療效、臨床癥狀積分、胃鏡情況、病理評分和Hp根除率均優于對照組，且可降低Survivin的錶達與提高Fas的錶達，兩組比較差異有統計學意義（P<0.05）。結論：健脾理氣方可以明顯改善慢性萎縮性胃炎癌前病變患者的臨床癥狀，減輕胃黏膜腸上皮化生和不典型增生程度，其中降低Survivin的錶達與提高的Fas錶達可能為其機製之一。
목적：관찰건비리기방대만성위축성위염암전병변적림상료효급기대조망기인Survivin여Fas표체적영향。방법：66례환자안안완전수궤화법분위량조，치료조화대조조각33례。치료조구복건비리기방，대조조구복위복춘편，량조균치료12주。관찰량조환자적종합료효、림상증상、위경정황、병리정황、유문라선간균（Hp）근제솔급Survivin여Fas표체정황。결과：치료조적종합료효、림상증상적분、위경정황、병리평분화Hp근제솔균우우대조조，차가강저Survivin적표체여제고Fas적표체，량조비교차이유통계학의의（P<0.05）。결론：건비리기방가이명현개선만성위축성위염암전병변환자적림상증상，감경위점막장상피화생화불전형증생정도，기중강저Survivin적표체여제고적Fas표체가능위기궤제지일。
Objective: To observe the clinical effect and the expression of Survivin and Fas of Jianpi Liqi Formula on patients with precancerous lesions of chronic atrophic gastritis.Method: 66 patients with precancerous lesions of chronic atrophic gastritis were equally randomized into two groups, which were the control group and the treatment group (n=33). In the treatment group Jianpi Liqi Formula decoction was given to the patients and in the control group Weifuchun tablets was given. Treated for 12 weeks, the total effective rate, clinical symptoms, gastroscopic images, pathological changes of gastric mucous membranes, Hp-eradicating rates , the expression of Survivin and Fas were observed.Result: The total effective rate, clinical symptoms, gastroscopic images, pathological changes of gastric mucous membranes and Hp-eradicating rates of the treatment group was better than that of the control group (P<0.05). The expression of Survivin was suppressed and the expression of Fas was enhanced in the treatment group (P<0.05). Conclusion:Jianpi Liqi Formula can improve the symptoms in patients with precancerous lesions of chronic atrophic gastritis and prevent the development of precancerous lesions of chronic atrophic gastritis. The mechanism of the clinical effect is probably due to down-regulate Survivin expression and up-regulate Fas expression.
