CAJ | 학술논문

目的：分析N-末端脑钠素原（ NT-ProBNP）和超敏C反应蛋白（ hs-CRP）在小儿支原体肺炎并心肌损害中的应用价值。方法将我院确诊MPP并心肌损害71例患儿根据NYHA心功能分级标准，分为心功能Ⅰ级A组19例，心功能Ⅱ级B组18例，心功能Ⅲ级C组18例，心功能Ⅳ级D组16例，比较其cTnI、CK-MB、Hs-CRP和NT-ProBNP差异，并比较心功能Ⅳ级组未治疗、治疗7 d、15 dcTnI、CK-MB、Hs-CRP和NT-ProBNP差异。结果 B组cTnI、Hs-CRP和NT-ProBNP水平高于A组；C组cTnI、CK-MB、Hs-CRP和NT-ProBNP水平高于A组和B组；D组cTnI、CK-MB、Hs-CRP和NT-ProBNP水平高于A组、B组和C组；治疗7 d时cTnI、CK-MB、Hs-CRP 和NT-ProBNP 结果入院时明显降低，治疗15 d 时 cTnI、Hs-CRP 和 NT-ProBNP结果较入院时及治疗7 d时明显降低，其CK-MB结果较入院时检查有差异（ P均＜0．05）。结论 NT-ProBNP和hs-CRP是小儿肺炎支原体肺炎并心肌损害安全、有效、全面的检查手段。
목적：분석N-말단뇌납소원（ NT-ProBNP）화초민C반응단백（ hs-CRP）재소인지원체폐염병심기손해중적응용개치。방법장아원학진MPP병심기손해71례환인근거NYHA심공능분급표준，분위심공능Ⅰ급A조19례，심공능Ⅱ급B조18례，심공능Ⅲ급C조18례，심공능Ⅳ급D조16례，비교기cTnI、CK-MB、Hs-CRP화NT-ProBNP차이，병비교심공능Ⅳ급조미치료、치료7 d、15 dcTnI、CK-MB、Hs-CRP화NT-ProBNP차이。결과 B조cTnI、Hs-CRP화NT-ProBNP수평고우A조；C조cTnI、CK-MB、Hs-CRP화NT-ProBNP수평고우A조화B조；D조cTnI、CK-MB、Hs-CRP화NT-ProBNP수평고우A조、B조화C조；치료7 d시cTnI、CK-MB、Hs-CRP 화NT-ProBNP 결과입원시명현강저，치료15 d 시 cTnI、Hs-CRP 화 NT-ProBNP결과교입원시급치료7 d시명현강저，기CK-MB결과교입원시검사유차이（ P균＜0．05）。결론 NT-ProBNP화hs-CRP시소인폐염지원체폐염병심기손해안전、유효、전면적검사수단。
Objective This article was to analyze the application efficacy of NT-ProBNP and hs-CRP in children suffered mycoplasma pneumonia combined with myocardial damage.Methods According to NYHA cardiac functional grading standards,the 71 cases of children with mycoplasma pneumonia and myocardial damage were divided into group A( Heart function at grade I, 19 cases) ,group B ( Heart function at grade II, 18 cases) , group C ( Heart function at grade III, 18 cases) and group D ( Heart function at grade IV, 16 cases) .Theconcentration of cTnI, CK-MB, hs-CRP and NT-proBNP were detected and compared. The changes of concentration of cTnI,CK-MB,hs-CRP and NT-proBNP in group D were compared.Results The concentration of cTnI、Hs-CRP and NT-ProBNP in group B were higher than that in group A.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP in group C were higher than that in group A and B.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP in group D were higher than those in group A, B and C.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP of group D after 7 days been treated were lower than those untreated.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP of group D after 15 days been treated were lower than those at 7th day been treated and untreated,CK-MB decreased compared with the concentration when patients were hospitalized (P<0.05).Conclusions NT-ProBNP and hs-CRP are safe, effective and comprehensive inspection means in diagnose children mycoplasma pneumonia combined with myocardial damage.